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A. Vieira



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    P1.01 - Poster Session with Presenters Present (ID 453)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Epidemiology/Tobacco Control and Cessation/Prevention
    • Presentations: 2
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      P1.01-053 - Lung Cancer in Brazil: Men and Women Differences (ID 6270)

      14:30 - 14:30  |  Author(s): A. Vieira

      • Abstract

      Background:
      The objective of this study was to describe the trends of histology and age of patients with non-small cell lung cancer (NSCLC) treated with lung resection according to gender. The histology of lung cancer is changing in developed countries and there is still little information available for developing countries.

      Methods:
      Retrospective analysis of all patients (N=1030) with resected NSCLC between 1986 and 2015 in a university hospital of Southern Brazil. Differences in histology, stage and type of surgery were analyzed by sex and period (1986-1995, 1996-2005 and 2006-2015).

      Results:
      Most patients were males (64.5%), main histologic types were adenocarcinoma (44.5%) and squamous cell carcinoma (40.6%). Mean age at surgery was 56.5 years for women and 58.9 years for men in first period, and 62.2 for women and 64.6 for men in the last period (p<0.001), suggesting that it was approximately 2.4 years higher for men (p<0.001), in spite of the period. The proportion of histologic types were different by gender (p<0.001), showing that overall squamous cells carcinoma was more frequent in men (46.9%) than in women (29%), and the opposite occurred for adenocarcinoma (40.4% versus 51.8% for men and women, respectively). Analyses by period showed squamous cells carcinoma declined from around 38.9% in the first period to 23.2% in 2005-2015 for men, virtually equaling the proportion of adenocarcinoma in the last period. The proportion of adenocarcinoma in women increased from 11.9% in the first period to 24% in the last. Considering all NSCLC patients, females with adenocarcinoma represented 11.9% in the first and 24% in the last period. Figure 1



      Conclusion:
      As seen in developed countries, rates of lung cancer in females are rising over the last three decades, but have not surpassed men rates yet. Adenocarcinoma is consistently the most frequent histological type in women. In men squamous cell rate has decreased.

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      P1.01-054 - Lung Cancer: Histology, Gender and Age Changes Over Past 30 Years in Brazil (ID 6286)

      14:30 - 14:30  |  Author(s): A. Vieira

      • Abstract

      Background:
      Lung is the leading death cause cancer related worldwide when considering both genders. The great effort to reduce smoking and introduce of cigarette changed lung cancer epidemiology. In developed countries the increase of adenocarcinoma and decrease of squamous cell carcinoma are well known. Other characteristic reported is the rising number of with the disease. Better understanding of current lung cancer epidemiology is necessary to design public health strategies for prevention, diagnosis and treatment.

      Methods:
      Retrospective analysis of all patients with non small cell lung cancer submitted to anatomical lung resection between 1986 and 2015 in an University Hospital of South Brazil. Patients were divided in three periods 1986-1995, 1996-2005 and 2006-2015. The same pathologist group made histology diagnosis and all staging was updated according to the new IASLC 7th edition. All analyses were performed using the SAS program.

      Results:
      In our Institution 1030 patients underwent anatomical lung resection for lung cancer between 1986 and 2015. 64.5% were males, average age 62.1 years, 40.6% squamous cell carcinoma and 44.5% adenocarcinoma, 23% advanced stage IIIA. The female proportion increased from 26.6% on first period to 44.2% on last period. Mean age at surgery treatment was 56.4 years for women and 58.9 for men on first period, and 62.2 for woman and 64.6 for men on the last period (p<0.001). The proportion of squamous cell changed from initially 49.6%, then 43% to 34.8% on the last period (p<0.001). In comparison in the same sequence we have for adenocarcinoma prevalence starting on 38.1%, 41.2% and most recently 49.5%. Stage IIIA was predominant on all periods with 23%, however early stages IA and IB combined represent 47.1% in the last group. Type of surgery was predominantly lobectomy and was verified decreasing in pneumonectomy rate.

      Conclusion:
      Analyses including gender showed that lung cancer in women is raising over the years but didn’t surpassed men yet. Women adenocarcinoma has increased the participation on total cases. The significant decrease of pneumonectomy reinforces the changes on surgical management technics and also correlates with more early staging diagnosis. The mean average age on surgery has increased for both men and women.

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    P1.07 - Poster Session with Presenters Present (ID 459)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: SCLC/Neuroendocrine Tumors
    • Presentations: 1
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      P1.07-052 - Pulmonary Neuroendocrine Tumors: Single Institution Experience in Brazil (ID 5816)

      14:30 - 14:30  |  Author(s): A. Vieira

      • Abstract

      Background:
      The primary lung neuroendocrine tumors (NET) are uncommon. They have a wide spectrum of clinical behavior, currently being classified into four types: tumor typical carcinoid (low grade malignancy), atypical carcinoid (intermediate malignancy grade), neuroendocrine large cells carcinoma and small cells. Neuroendocrine lung tumors represent a large and heterogenic group with different management and survival rates. Little information regarding neuroendocrine tumors is available for Latin American countries.

      Methods:
      Retrospective service database review of patients with NET treated at Hospital São Lucas in Porto Alegre, Brazil between 1991-2015. Inclusion criteria were age 18 or older with histologically or immunochemistry confirmed neuroendocrine tumor. For analysis purposes we divided between, typical carcinoid, atypical carcinoid and poorly differentiated (large and small cells).

      Results:
      From January of 1991 to December of 2015, of 946 lung cancer resections 49 patients with NET were resected. Most the patients were female (57,1%), mean age 55 years (28- 84 years). Typical carcinoid represented 63,3% of patients, followed by atypical carcinoid (22,4%) and poorly differentiated neuroendocrine tumors (14,3%). Mean age was 51,4 for typical carcinoid, 56 for atypical carcinoid and 63 for undifferentiated NET. Lobectomy was the surgical approach for 85,7%,, pneumonectomy was required for 4,1% and segmentectomy for 10,2% of patients. Minimally invasive (VATS) was done in 4,1%. Figure 1



      Conclusion:
      According to the European Consensus, pulmonary carcinoids account for 1–2% of all invasive lung malignancies. We found 85,7% of our lung resections were carcinoids and a higher mean age 51,4 for patients with typical and 56 for atypical carcinoids compared to the literature.