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M.T. Ruiz Tsukazan



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    P1.01 - Poster Session with Presenters Present (ID 453)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Epidemiology/Tobacco Control and Cessation/Prevention
    • Presentations: 2
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      P1.01-053 - Lung Cancer in Brazil: Men and Women Differences (ID 6270)

      14:30 - 14:30  |  Author(s): M.T. Ruiz Tsukazan

      • Abstract

      Background:
      The objective of this study was to describe the trends of histology and age of patients with non-small cell lung cancer (NSCLC) treated with lung resection according to gender. The histology of lung cancer is changing in developed countries and there is still little information available for developing countries.

      Methods:
      Retrospective analysis of all patients (N=1030) with resected NSCLC between 1986 and 2015 in a university hospital of Southern Brazil. Differences in histology, stage and type of surgery were analyzed by sex and period (1986-1995, 1996-2005 and 2006-2015).

      Results:
      Most patients were males (64.5%), main histologic types were adenocarcinoma (44.5%) and squamous cell carcinoma (40.6%). Mean age at surgery was 56.5 years for women and 58.9 years for men in first period, and 62.2 for women and 64.6 for men in the last period (p<0.001), suggesting that it was approximately 2.4 years higher for men (p<0.001), in spite of the period. The proportion of histologic types were different by gender (p<0.001), showing that overall squamous cells carcinoma was more frequent in men (46.9%) than in women (29%), and the opposite occurred for adenocarcinoma (40.4% versus 51.8% for men and women, respectively). Analyses by period showed squamous cells carcinoma declined from around 38.9% in the first period to 23.2% in 2005-2015 for men, virtually equaling the proportion of adenocarcinoma in the last period. The proportion of adenocarcinoma in women increased from 11.9% in the first period to 24% in the last. Considering all NSCLC patients, females with adenocarcinoma represented 11.9% in the first and 24% in the last period. Figure 1



      Conclusion:
      As seen in developed countries, rates of lung cancer in females are rising over the last three decades, but have not surpassed men rates yet. Adenocarcinoma is consistently the most frequent histological type in women. In men squamous cell rate has decreased.

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      P1.01-054 - Lung Cancer: Histology, Gender and Age Changes Over Past 30 Years in Brazil (ID 6286)

      14:30 - 14:30  |  Author(s): M.T. Ruiz Tsukazan

      • Abstract

      Background:
      Lung is the leading death cause cancer related worldwide when considering both genders. The great effort to reduce smoking and introduce of cigarette changed lung cancer epidemiology. In developed countries the increase of adenocarcinoma and decrease of squamous cell carcinoma are well known. Other characteristic reported is the rising number of with the disease. Better understanding of current lung cancer epidemiology is necessary to design public health strategies for prevention, diagnosis and treatment.

      Methods:
      Retrospective analysis of all patients with non small cell lung cancer submitted to anatomical lung resection between 1986 and 2015 in an University Hospital of South Brazil. Patients were divided in three periods 1986-1995, 1996-2005 and 2006-2015. The same pathologist group made histology diagnosis and all staging was updated according to the new IASLC 7th edition. All analyses were performed using the SAS program.

      Results:
      In our Institution 1030 patients underwent anatomical lung resection for lung cancer between 1986 and 2015. 64.5% were males, average age 62.1 years, 40.6% squamous cell carcinoma and 44.5% adenocarcinoma, 23% advanced stage IIIA. The female proportion increased from 26.6% on first period to 44.2% on last period. Mean age at surgery treatment was 56.4 years for women and 58.9 for men on first period, and 62.2 for woman and 64.6 for men on the last period (p<0.001). The proportion of squamous cell changed from initially 49.6%, then 43% to 34.8% on the last period (p<0.001). In comparison in the same sequence we have for adenocarcinoma prevalence starting on 38.1%, 41.2% and most recently 49.5%. Stage IIIA was predominant on all periods with 23%, however early stages IA and IB combined represent 47.1% in the last group. Type of surgery was predominantly lobectomy and was verified decreasing in pneumonectomy rate.

      Conclusion:
      Analyses including gender showed that lung cancer in women is raising over the years but didn’t surpassed men yet. Women adenocarcinoma has increased the participation on total cases. The significant decrease of pneumonectomy reinforces the changes on surgical management technics and also correlates with more early staging diagnosis. The mean average age on surgery has increased for both men and women.

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    P1.08 - Poster Session with Presenters Present (ID 460)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Surgery
    • Presentations: 1
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      P1.08-058 - VATS Lung Resection Analysis from Brazilian Society of Thoracic Surgery Database (ID 6252)

      14:30 - 14:30  |  Author(s): M.T. Ruiz Tsukazan

      • Abstract

      Background:
      Lung cancer is the leading cause of cancer related death worldwide when considering both genders. The optimal treatment is complete surgical resection. The objective of this study was to analyze VATS anatomic lung resections in Brazil.

      Methods:
      The Brazilian Society of Thoracic Surgery (BSTS) uses a customized version of the ESTS platform as its national database (BSTS Database). From August to December 2015, 1367 patients were registered. In the current analysis, we included only patients who underwent lung cancer anatomic lung resections by VATS; wedge resections and unspecified cases were excluded.

      Results:
      Out of the 902 anatomical lung resections registered, 516 were lung cancer and VATS performed in 389. Patient’s mean age was 62.5 years, 57.7% were women. PFT were available in 239 with FEV1 81.7% and CFV 88%. ASA score (n=352) was 1 in 19.3%, 2 in 49.7%, 3 in 27.3%, 4 in 3.4% and 5 in 0.3%. The resections performed were lobectomy in 303 cases (77.9%), pneumonectomy in 9 (2.3%), bilobectomy in 5(1.3%) and segmentectomy in 72 (18.5%). Morbidity rate was 21.8% and it varied according to the procedure performed. Overall mortality rate was 1.6% (6). Pathological staging was In situ in 1.3%, IA 55.6%, IB 20.1%, IIA 11.7%, IIB 1.7%, IIIA 9.6% and no IV.

      Conclusion:
      Slightly female predominance and majority of early stage IA and IB lung cancer were found. Our BSTS Database has comparable complications and mortality rates to international series.