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É. Leroy-Terquem
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P1.01 - Poster Session with Presenters Present (ID 453)
- Event: WCLC 2016
- Type: Poster Presenters Present
- Track: Epidemiology/Tobacco Control and Cessation/Prevention
- Presentations: 1
- Moderators:
- Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)
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P1.01-038 - Prognosis Value of Body Mass Index (BMI) and Weight Loss at Diagnosis in Primary Lung Cancer: Results of KBP-2010-CPHG Study (ID 4373)
14:30 - 14:30 | Author(s): É. Leroy-Terquem
- Abstract
Background:
We studied the relationship between 1-year mortality and weight at diagnostic in 6,965 adult patients followed for primary lung cancer in 104 general hospitals.
Methods:
Patients were classified into 5 groups: Group 1, underweight with recent weight loss; Group 2, underweight without recent weight loss; Group 3, normal weight; Group 4, overweight; Group 5, obese. Kaplan-Meier method (1-year mortality) and Cox multivariate analysis (independent risk-factors) were used.
Results:
Respectively, 11%, 4%, 45%, 29%, and 12% of patients belonged to Groups 1, 2, 3, 4, and 5. One-year survival was lower in Group 1 (27% [24%-30%]) and higher in Group 4 (50% [48%-52%]) or 5 (53% [50%-57%]) than in Group 2 (47% [41%-53%]) or 3 (43% [42%-45%]) (Fig. 1). As compared with normal weight, overweight was an independent protective factor. Independent protective/risk factors are presented in Table 1. Interaction analyses showed that overweight was a significant independent protective factor for stage IIIA and IIIB cancer (HR=0.77 [0.6-0.99], p=0.038; HR=0.75 [0.59-0.97], p=0.029, respectively). Figure 1Variable HR 95%CI P BMI (group) 3 1 1 1.06 0.96-1.17 0.26 2 1.03 0.85-1.23 0.789 4 0.92 0.85-0.99 0.036 5 0.9 0.81-1.01 0.061 Age (years) <=40 1 41-50 1.07 0.74-1.54 0.714 51-60 1.02 0.72-1.46 0.899 61-70 1.05 0.74-1.49 0.796 71-80 1.11 0.78-1.59 0.553 >80 1.54 1.07-2.22 0.02 Sex Men 1 Women 0.81 0.74-0.88 <0.001 Smoking Never-smoker 1 Former-smoker 1.19 1.06-1.35 0.004 Current-smoker 1.27 1.13-1.44 <0.001 PS PS0 1 PS1 1.58 1.45-1.73 <0.001 PS2 2.66 2.4-2.95 <0.001 PS3 5.6 4.95-6.34 <0.001 PS4 10.61 8.62-13.05 <0.001 Stage <=IIB 1 IIIA 1.89 1.61-2.21 <0.001 IIIB 3 2.56-3.52 <0.001 IV 4.71 4.13-5.38 <0.001
Conclusion:
In 2010, in France, in real life conditions, 1-year survival was low in lung cancer patients with low BMI at diagnosis and recent weight loss. Overweight appeared to be a protective factor in particular for stage IIIA and IIIB cancers.
