Author of

• 16489

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  P1.01 - Poster Session with Presenters Present (ID 453)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Epidemiology/Tobacco Control and Cessation/Prevention
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16526

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    P1.01-037 - Baseline Demographics and Comorbidities of Patients with Advanced NSCLC Compared to the General Population from Two Regions in Sweden (ID 4908)

    14:30 - 14:30  |  Author(s): P. Verpillat
    • Abstract
    • Slides

    Background:
    Lung cancer is the most commonly diagnosed cancer in men and the third most common in women. However, detailed analyses of patient newly diagnosed with advanced non-small cell lung cancer (NSCLC) in routine clinical care, compared to the general population, is limited.
    
    Methods:
    This non-interventional study is based on existing data from the population-based national Swedish Cancer Registry. All adult patients diagnosed with advanced NSCLC between 2006 and 2013 receiving care in the regions of Skåne and Västra Götaland counties (about 37.6% of NSCLC patients in Sweden) were included and matched (1:4) by age at diagnosis, gender and region of residence to a sample from the general population (controls). In- and outpatient visit data was extracted from regional databases in order to assess prevalence of selected baseline comorbidities detected in the year before diagnosis.
    
    Results:
    In total, 4,758 patients with advanced NSCLC were identified and matched to 18,996 controls. At the date of the initial NSCLC diagnosis, the median age was 69.0 (range 22-97; 96.2% above 50), and 52.7% were men. The stage of disease was IIIb in 19.8% (n=944) or IV in 80.2% (n=3,814) of the patients. When specified, adenocarcinoma was the most frequent histology (70.4%) followed by squamous cell carcinomas (25.4%). A total of 50.9% of the NSCLC patients had recorded morbidities in the year preceding the diagnosis compared to 34.8% of the controls (Odds Ratio (OR) 1.94; P<0.001)). Patients with advanced NSCLC had significantly more often (P<0.001) respiratory disorders (16.4% vs. 3.2%; OR 6.02), infections (13.4% vs 6.1%; OR 2.37), anaemia (3.4% vs. 1.7%; OR 2.08), musculoskeletal disorders (3.7% vs. 2.5%; OR 1.51), and cardiovascular disease (27.8% vs. 22.7%; OR 1.31). No significant difference was observed in prevalence of gastro-intestinal disorders, metabolic disorders or skin disorders. Regarding disorders of the central nervous system, while depression was more frequently present among NSCLC patients (3.8% vs. 2.8%; OR 1,38) dementia was more prevalent among controls (0.6% vs. 1.2%; OR 0.48). As expected, brain metastasis was diagnosed overwhelmingly more for NSCLC patients (53 cases, vs. 2 cases; OR 107.0).
    
    Conclusion:
    The present study suggests that patients diagnosed with advanced NSCLC have a significantly higher morbidity burden than the general population in these regions in Sweden.
    
    

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