Author of

• 16489

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  P1.01 - Poster Session with Presenters Present (ID 453)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Epidemiology/Tobacco Control and Cessation/Prevention
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16520

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    P1.01-031 - Does Malignant Pleual Mesothelioma (MPM) Behaviour Differ among Decades? (ID 6210)

    14:30 - 14:30  |  Author(s): M. Rahoma
    • Abstract

    Background:
    MPM is extremely aggressive and has a long-latency period. Hence, detected at advanced stages resulting in an unfavorable prognosis(1-2years). However,MPM prognosis has been improving over the past few years with availability of better diagnostic and treatment regimens. We aim to compare clinico-pathologic characteristics of old-MPM cases referred to National Cancer Institute(NCI)-Cairo university between( 2002-2003)and new MPM cases(2012-2015)
    
    Methods:
    Retrospective review of MPM cases presented to NCI..Data regarding demographics, histology, symptoms and signs, tumor staging and CT-findings were obtained from all patients’ records. Pearson's Chi(X2)and Fisher's Exact t-tests were used for statistical analysis.
    
    Results:
    1)Old cohort(n=100): 100 patients were encountered. Median age was 46years.Males were 59% of cases. 30% has PS1. Asbestos exposure was documented in 74cases. 44cases were smokers, 25cases were industrial-workers. Family history was positive in 12cases.Dyspnea was the presenting symptom in 92cases,chest pain in 83% and tuberculous pleuritis in 2 cases, effusion in all cases, pleural thickening in 80%,tracheal shift to the opposite-side in 23%, T2 represented 41%. Epithelioid subtype 46.6%. Pathological T2= 34%. 2)New cohort(n=194): 194 patients were encountered.Median age was 53 years.Males and females were nearly equally distributed. Epithelioid subtype was 63.4%. Rt-sided lesions were evident in nearly two-thirds of the cases.Pleural thickening was nodular in 131(69.7%)cases. Inter-lobar fissure was thickened in 29.4%. Mediastinal Pleura was affected in 37.1%. Nearly,half of our cases had effusion.Ossification & calcification were detected in 8(4.1%) cases. Contraction of hemithorax was identified in 77(39.7%)cases. Chest wall invasion(CWI)was present in 18(9.3%) cases. Pulmonary nodules were detected in one-fifth of the cohort. Metastases were detected in 9(4.6%)cases(Figure).Figure 1
    
    
    
    Conclusion:
    By comparing both groups, we found that more lymph node involvement(N+), less metastasis(M+),older median age,more females, more epithelial subtype, less pleural effusion presentation, more pleural thickening were detected in group 2(new cases) reflecting better staging ( mediastinoscopy& PET-CT),early detection, more incidence in females and better treatment modalities.