Author of

• 16489

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  P1.01 - Poster Session with Presenters Present (ID 453)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Epidemiology/Tobacco Control and Cessation/Prevention
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16495

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    P1.01-006 - Interstitial Lung Diseases Are an Antecedent of Lung Cancer (ID 5353)

    14:30 - 14:30  |  Author(s): W. Choi
    • Abstract

    Background:
    Diffuse pulmonary fibrosis may progress into lung cancer through continuous accumulation and rapid proliferation of fibroblasts and repeated epithelial injury. Repetitive injury and repair can lead to multiple genetic alterations affecting cellular growth, differentiation, and survival, which may elicit malignant potential in the injured area. Diffuse pulmonary fibrosis appears on chest images through expression of bilateral reticular or reticulonodular opacities, called interstitial lung diseases. The clinical significance of these diseases remains poorly understood. To investigate whether interstitial lung diseases increase lung cancer incidence in a cohort of patients from a national population.
    
    Background:
    Diffuse pulmonary fibrosis may progress into lung cancer through continuous accumulation and rapid proliferation of fibroblasts and repeated epithelial injury. Repetitive injury and repair can lead to multiple genetic alterations affecting cellular growth, differentiation, and survival, which may elicit malignant potential in the injured area. Diffuse pulmonary fibrosis appears on chest images through expression of bilateral reticular or reticulonodular opacities, called interstitial lung diseases. The clinical significance of these diseases remains poorly understood. To investigate whether interstitial lung diseases increase lung cancer incidence in a cohort of patients from a national population.
    
    Results:
    A nationwide retrospective cohort study using Korean Health Insurance Review and Assessment Service data, including 13,666 patients with interstitial lung disease (6.4% with concomitant idiopathic pulmonary fibrosis) diagnosed January–December 2009. The end of follow-up was June 31, 2014. Up to four matching chronic obstructive pulmonary disease controls with and without concomitant interstitial lung disease (8,012 cases) were selected to compare the lung cancer high-risk group. Lung cancer was counted after diagnosis of interstitial lung disease, idiopathic pulmonary fibrosis, or chronic obstructive pulmonary disease.
    
    Conclusion:
    The incidence of lung cancer was 126.9 cases per 10,000 person-years (2,732 cancers) in the chronic obstructive pulmonary disease group, 156.6 (809 cancers) in the interstitial lung disease group, and 370.3 (967 cancers) in the chronic obstructive pulmonary disease with interstitial lung disease group. Among various interstitial lung disease definitions, idiopathic pulmonary fibrosis showed the highest lung cancer incidence. A total of 112 of the 879 patients with idiopathic pulmonary fibrosis developed lung cancer, an incidence of 381 cases per 10,000 person-years. Interstitial lung diseases have high potential to develop into lung cancer even when combined with chronic obstructive pulmonary disease.