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A. Uhlhorn
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P3.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 226)
- Event: WCLC 2015
- Type: Poster
- Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.08-018 - Clinical and Pathologic Characteristics of Bronchial Carcinoid Tumors: A Single Institution Review (ID 2858)
09:30 - 09:30 | Author(s): A. Uhlhorn
- Abstract
Background:
Typical and atypical carcinoids represent about 2% of all lung tumors. Unlike most lung tumors, survival of patients with typical bronchial carcinoids is generally long but and is dependent on stage. We report the findings from the Ochsner/Louisiana State University (LSU) Neuroendocrine Tumor (NET) Program.
Methods:
A database with all patients who were seen at the Ochsner/LSU NET Program was queried for all bronchial NET patients. We included those who had confirmed pathological bronchial carcinoid and those who had at least one visit to our clinic. Typical and atypical bronchial carcinoids were defined by most recent WHO classification. Excluded were patients with large and small cell NETs, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, and inaccessible patient records.
Results:
One-hundred sixty-nine patients were included from January 1996 - March 2015. The mean age at diagnosis was 53 (range 12-92). There were 154 (91%) Caucasian, 10 (6%) African-American, and 5 (3%) other. Females represented 67% of all patients. 51% percent (86/169) were well differentiated, 12% (21/169) were moderately differentiated. Eighty-five percent and fifty-three percent were positive on PET and octreotide scanning, respectively. One-hundred fifty-five patients had adequate staging information. Overall survival and survival by stage and differentiation status is shown below. There was a statistically significant difference in survival by Ki-67 index.
* A and B stages are grouped Figure 1Overall Survival N Median 5-year 10-year 169 243 months 88% 74% Survival by AJCC 7 Stage N 5-year 10-year I* 65 98% 91% II* 23 95% 87% III* 27 84% 66% IV 40 73% 49% Survival by Differentiation Status Median 5-year 10-year Well (n=86) 243 88% 81% Moderate (n=21) 119 80% 42% Survival by Typical/Atypical Median 5-year 10-year Typical (n=109) 243 months 89% 80% Atypical (46) 126 months 84% 59%
Conclusion:
Overall, patients with bronchial carcinoids experience high 5 and 10-year survival rates. As expected, there were significant survival differences between nodal status, differentiation status and typical versus atypical. Interestingly, there was a statistically significant difference in survival between low, low-intermediate and high-intermediate Ki-67 values. Our analysis showed that survival rates were much better for Ki-67 index value ranges from 0-2% versus >2-10% versus >10-20%. As with gastroenteropancreatic NETs, Ki-67 index could become a valuable prognostic indicator for bronchial carcinoids.
