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G. Zhang
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P3.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 235)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.04-132 - Expression of nm23 and CD44v6 Proteins in Non-Small Cell Lung Cancer and Their Clinical Significance (ID 1473)
09:30 - 09:30 | Author(s): G. Zhang
- Abstract
Background:
To investigate the expression of nm23 and CD44v6 proteins in non-small cell lung cancer (NSCLC) and their clinical significance.
Methods:
The expression of nm23 and CD44v6 proteins was detected in 58 NSCLC samples using two-step immunohistochemistry.
Results:
The overall positive rate of nm23 was 87.9% (51/58), and significant difference was presented between T1～T2 groups and T3～T4 groups (P<0.05). The overall positive rate of CD44v6 was 55.2% (32/58), in which that of squamous cell carcinoma was dramatically higher than that of adenocarcinoma (85.7% vs. 24%, P<0.05). The positive rate of moderately-differentiated group was higher than that of poorly-differentiated group (71.9% vs. 44.4%, P<0.05). The expression of nm23 and CD44v6 was not associated with pTNM staging, lymph node metastasis and survival rate (P>0.05).
Conclusion:
The expression of nm23 and CD44v6 proteins is correlated with the tumor size (T), pathological types and differentiated degrees of NSCLC instead of pTNM staging and lymph node metastasis.
