Author of

• 15382

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  P3.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 235)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Biology, Pathology, and Molecular Testing
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 15514

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    P3.04-132 - Expression of nm23 and CD44v6 Proteins in Non-Small Cell Lung Cancer and Their Clinical Significance (ID 1473)

    09:30 - 09:30  |  Author(s): P. Aerxiding
    • Abstract
    • Slides

    Background:
    To investigate the expression of nm23 and CD44v6 proteins in non-small cell lung cancer (NSCLC) and their clinical significance.
    
    Methods:
    The expression of nm23 and CD44v6 proteins was detected in 58 NSCLC samples using two-step immunohistochemistry.
    
    Results:
    The overall positive rate of nm23 was 87.9% (51/58), and significant difference was presented between T1～T2 groups and T3～T4 groups (P<0.05). The overall positive rate of CD44v6 was 55.2% (32/58), in which that of squamous cell carcinoma was dramatically higher than that of adenocarcinoma (85.7% vs. 24%, P<0.05). The positive rate of moderately-differentiated group was higher than that of poorly-differentiated group (71.9% vs. 44.4%, P<0.05). The expression of nm23 and CD44v6 was not associated with pTNM staging, lymph node metastasis and survival rate (P>0.05).
    
    Conclusion:
    The expression of nm23 and CD44v6 proteins is correlated with the tumor size (T), pathological types and differentiated degrees of NSCLC instead of pTNM staging and lymph node metastasis.
    
    

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