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M. Maroules
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P3.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 235)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.04-131 - Relationship between Peripheral Basophil Count and Non Small Cell Lung Cancer (ID 2587)
09:30 - 09:30 | Author(s): M. Maroules
- Abstract
Background:
Lung cancer is the second most common cancer diagnosed in men and women after prostate and breast respectively. Basophils are the novel targets in cancer directed immunotherapy. We propose to study co-relationship between absolute counts of peripheral basophils in patients with NSCLC.
Methods:
The study was conducted at 651 bedded tertiary care teaching hospital in Northern New Jersey, USA. The protocol was classified as “exempt” by the hospital’s institutional review board. The study included 561 patients with a primary diagnosis of NSCLC registered with the hospital’s tumor registry from January 2001 to June 2011. Medical records were reviewed for these patients and Age, sex, race, WBC count, absolute basophilic count, histological type and TNM staging of all patients was noted at the time of diagnosis. The exclusion criteria were: 1. Patients whose biopsy reports were unavailable in the medical records or 2. Patients whose TNM Stage or Absolute Basophil Counts were unavailable at the time of diagnosis or 3. 18 years or less in age at the time of diagnosis. Data analysis was done using Microsoft Office Excel, 2007.
Results:
Mean age for the diagnosis was 67.6±11.1 year. Adenocarcinoma (49.1%) was the most common diagnosis followed SCC (40.9%). Caucasians (61%) were more commonly diagnosed adenocarcinoma and SCC then African Americans (25.7%) & other races (13.2%). Males (64.2%) were more commonly diagnosed than females. Most of the cancers were diagnosed in the late stages (Stage III; 25.7% & Stage IV; 32.9%) accounting for 58.6% of the tumor burden. Mean White blood cell (WBC) count was 9.34±5.56 (*10[3]/mm[3]). There were no statistically significant differences noticed in WBC counts based on histology for Adenocarcinoma: 8.66±4.16 (p=0.103) and SCC: 9.71±5.69 (p=0.453) except other cancers: 11.20±9.26 (p=0.046). Mean peripheral basophil count (PBC) was 0.0959±0.099 (*10[3]/mm[3]). Based on histological types, there were no statistically significant differences noticed in PBC counts for Adenocarcinoma: 0.0897±0.0851 (p=0.418) and SCC: 0.0961±0.1048 (p=0.976) other cancers: 0.1253±0.1283 (p=0.06). Further, we assumed PBC of stage1 as baseline for all the cancers subtypes and compared PBC with stage II, III & IV using student t-test (table 2). There was no statistical difference between PBC with any stages and histological subtypes. With the p-value trending towards significance in other cancers group. Mean PBC was statistically higher for the Undifferentiated cancers (p= 0.0359; 95% CI ±0.048). NSCLC weakly correlated with absolute basophils (Adjusted R[2] = -0.000228, p = 0.70). Median interval change did not vary significantly between stages of adenocarcinoma and SCC (Kruskal-Wallis p value: 0.8702, 0.5798 respectively).
Conclusion:
Though, the study was unable to demonstrate any relationship between peripheral basophil count and adenocarcinoma or SCC of lung. But surprisingly, there is a positive relationship between Undifferenciated lung cancer and PBC. But to translate this result in clinical significance will be difficult as absolute PBC may be very small. The mean age of diagnosis and male sex being predominantly affected corroborates with the current literature. We recommend further studies to compare the PBC in NSCLC patients with age, gender and ethnicity matched population controls
