Author of

• 15343

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  P3.03 - Poster Session/ Treatment of Locoregional Disease – NSCLC (ID 214)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Treatment of Locoregional Disease – NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 15374

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    P3.03-031 - Predictors of Radiation Pneumonitis and Associated Changes of Pulmonary Function After Definitive Concurrent Chemoradiotherapy in NSCLC (ID 1490)

    09:30 - 09:30  |  Author(s): Y.H. Park
    • Abstract

    Background:
    To evaluate the predictive factors of radiation pneumonitis (RP) and associated changes of pulmonary function after definitive concurrent chemoradiotherapy (CCRT) in patients with NSCLC
    
    Methods:
    Medical records of 61 patients with NSCLC who received definitive CCRT at Seoul National University Bundang Hospital were retrospectively reviewed. Dose volumetric parameters, clinical factors, pulmonary function test (PFT) data were analyzed. RP was graded according to the Common Terminology Criteria for Adverse Events v3.0. Percentage of lung volume that received a dose of 10 Gy or more (V10), 20 Gy or more (V20), 30 Gy or more (V30), mean lung dose (MLD) were analyzed for potential dose volumetric (DV) parameters. PFT changes were calculated as the difference between pre-RT and post-RT values compared to the pre-RT values at 3, 6, 12 months after RT. Tumor location was categorized two groups, upper (including middle) and lower lobe.
    
    Results:
    The overall and progression-free survival time were 21.9 month and 10.6 months. Twenty-three patients (38%) developed grade≥2 RP. Among clinical factors, underlying chronic obstructive pulmonary disease was associated with RP (p=0.050) but not with grade ≥2 RP (p=0.871). Tumor located at lower lobe was associated with grade ≥2 RP (p=0.002). Among the DV parameters, only MLD > 15 Gy was associated with grade ≥2 RP (p=0.009). There were statistically significant decreases in PFT values at all points compared with pre-RT values. MLD was associated with magnitude of forced vital capacity (FVC) changes at 6/12 months (p=0.006/0.016) and forced expiratory volume in 1 s (FEV1) changes at 6 months (p=0.005). V10 and V20 were associated with FVC changes at 12 months (p=0.048/0.025) and V30 was associated with diffusion capacity for carbon monoxide changes at 6 months (p=0.023).
    
    Conclusion:
    MLD > 15 Gy and lower lobe tumor were predictors of grade ≥2 RP. Pulmonary functions were decreased after CCRT and the magnitude of change was associated with DV parameters.