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C. Son
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P3.03 - Poster Session/ Treatment of Locoregional Disease – NSCLC (ID 214)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Locoregional Disease – NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.03-025 - Fatal and near Fatal Radiation Lung Injury after Lung Cancer Treatment (ID 2664)
09:30 - 09:30 | Author(s): C. Son
- Abstract
Background:
Radiotherapy is important, and potentially curative method of treatment in lung cancer. Radiation pneumonitis and fibrosis is very frequent complication of radiotherapy, but usually asymptomatic or mild. Sometimes, however, it is fulminant and fatal. We reviewed clinical characteristics of fatal and near fatal form of radiation lung injury after lung cancer treatment.
Methods:
We retrospectively reviewed medical records of patients with lung cancer who received radiation on thorax greater than 50 Gy from January 2006 to December 2014, and clinical, radiologic, and pathologic characteristics were assessed.
Results:
Three hundred forty two patients were received thoracic radiation greater than 50 Gy. Radiation lung injury was observed in 284 patients(74.3%), and in 177 patients(62.3%) those lung injury was asymptomatic and mild fibrosis confined in directly radiated lung field. Fatal and near fatal radiation pneumonitis were developed in 39 patients(11.4%), of them 25 patients(7.3%) died of respiratory failure. In 25 patients, 13 patients(52.0%) had pre-existing interstitial lung disease, 16 patients(64.0%) received chemotherapy concurrently. All the fatal lung injuries were extensive consolidation and ground glass opacity out of radiation field.
Conclusion:
Radiation lung injury is usually mild and asymptomatic, however extensive radiation pneumonitis out of radiation field is fatal and near fatal. Concurrent chemoradiation and pre-existing interstitial lung disease were risk factors of this fulminant lung injury.
