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M. Wong Jaen
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P3.03 - Poster Session/ Treatment of Locoregional Disease – NSCLC (ID 214)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Locoregional Disease – NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.03-002 - Risk Factors and Outcomes of Pneumonectomy in Patients with Lung Cancer (ID 2947)
09:30 - 09:30 | Author(s): M. Wong Jaen
- Abstract
Background:
Pneumonectomy has been associated with high morbidity and mortality. The aim of this study is to evaluate complications, risk factors of mortality and overall survival of patients undergoing pneumonectomy for lung cancer.
Methods:
Retrospective study of 380 consecutive patients operated between January 2004 and December 2014. The majority were male (87, 4%), with a mean age of 60.7 years (r: 29-81) and a mean follow-up of 31.7 months.
Results:
Right pneumonectomy was the most frequent procedure (58.2%). Most of the patients were diagnosed with squamous cell carcinoma (56.1%). Half of the patients received neoadjuvant chemotherapy (50.5%) and 18 (4.7%) concomitant radiotherapy. N2 disease was present in 125 patients (32.9%). Figure 1 The most frequent complication was atrial fibrillation (14%). Twenty-seven patients (7.1%) required reoperation for postoperative bleeding. Bronchopleural fistula appeared in 54 patients (14.21%). Twenty-five patients (6.6%) died within 30-days after surgery. Overall survival was 36.6% months with rates at 1, 3 and 5 years of 73.2%, 42.5% and 31,2% respectively. Figure 2 Survival according to tumor size showed significant differences (T1: 33.1 months, T2: 21.1 months, T3: 11.4 months and T4:10.3 months). Survival was lower in patients with N2 disease (10.8 vs 30 months, p=0.0000). Overall survival was higher for left pneumonectomy (17.6 vs 24.8 months).There were significant differences in survival when analyzing lung function parameters, histological type, cancer stage, neoadjuvant treatment, pulmonary or cardiac complications, and reoperation for postoperative bleeding.
Conclusion:
In our series, age, side of resection, lung capacity, tumor extension, extent of surgical resection, comorbidities and postoperative complications are associated with decreased survival.
