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S. Adebahr
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-027 - Surgical Salvage Resection for Local Recurrence after Stereotactic Body Radiotherapy for Primary and Metastatic Lung Tumors (ID 2600)
09:30 - 09:30 | Author(s): S. Adebahr
- Abstract
Background:
Stereotactic body radiation therapy (SBRT) is an alternative to surgery for the treatment of early stage lung cancer or solitary metastasis in high-risk individuals. The aim of the study was to identify patients that underwent surgical resection as a salvage therapy for local recurrences following SBRT.
Methods:
In a single institution prospective database patients that underwent SBRT for early-stage NSCLC or pulmonary metastatic tumors were identified over 5 years. Patients that underwent surgical salvage resection for local recurrences after SBRT were analyzed for clinicopathological data and outcome.
Results:
In 4/188 (2.1%) patients salvage surgery was performed for local recurrences after SBRT within a median period of 14.5 months. SBRT was performed with a total dosage of 35 Gy in 3 and 37.5 Gy in 1 patient. No perioperative mortality occurred after salvage resection, and complete resection was achieved in all cases. Histopathology demonstrated viable tumor cells accompanied by fibrosis and necrosis in all resected specimens.
Conclusion:
Salvage surgery should be considered in operable patients after lung SBRT for primary and metastatic tumors as viable tumor can be expected. It can be performed safely in appropriate candidates that need to be identified in a multidisciplinary setting. Further analysis of larger series could further clarify true incidence of local recurrences after SBRT and selection criteria for salvage surgery in this challenging group of patients.
