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T. Yamamoto
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-007 - Survival and Prognostic Factor in Pathological N1 Non-Small-Cell Lung Cancer (ID 2750)
09:30 - 09:30 | Author(s): T. Yamamoto
- Abstract
Background:
The 5-year survival rates of N1 non-small-cell lung cancer (NSCLC) were reported to be between 27% and 67%. The aim of the study was to identify common prognostic factors in NSCLC with N1 nodal involvement.
Methods:
The medical records and the follow-up data of the patients operated for NSCLC(p-N1) between January 1991 and December 2013 in Yokohama Rosai Hospital were analyzed retrospectively. Fifty-four patients with NSCLC (p-N1) who underwent lung resections with negative surgical margins were included in this study.
Results:
The subjects were 45 men and 9 women with a mean age of 67 years (range, 45-81 years). Among them 24 had adenocarcinoma, 16 had squamous cell carcinoma, 6 had large cell carcinoma, and 8 had the other histologies. T-factor of the primary tumor was T1 in 12 patients, T2 in 34, T3 in 7, and T4 in 1. Among N1 disease, peripheral zone lymph node (#12,13,14) metastasis was 18 cases, while hilar zone node(#10,11) metastasis was 30 cases, and both zone in 6 cases. The overall 5-year survival rates were 54.7 % in N1 disease. In a univariate analysis, survival was worse in case of higher T factor (T3,4) (p<0.01), multiple-N1-node involvement(p<0.01), and multiple-N1-zone involvement(p<0.01). Among patients with single-N1-zone involvement, overall survival was lower in patients with hilar zone metastasis than in those with peripheral zone metastasis, although this difference was not statistically significant (p=0.272).Figure 1
Conclusion:
In pN1 NSCLC patients, higher T-factor, multiple-N1-node involvement, and multiple-N1-zone involvement were worse prognostic factors.
