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S. Margunato-Debay
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P3.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 208)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.01-059 - Treatment Intensity and Duration in Patients Receiving First-Line Nab-paclitaxel or Paclitaxel (Weekly or Every 3 weeks) for Stage IV Non-Small Cell Lung Cancer (NSCLC): A Retrospective Analysis Utilizing Electronic Medical Records (ID 1569)
09:30 - 09:30 | Author(s): S. Margunato-Debay
- Abstract
Background:
In a phase III trial, weekly nab-paclitaxel (nab-P) plus carboplatin demonstrated a significantly higher response rate than paclitaxel (P) plus carboplatin every 3 weeks, with less grade ≥ 3 neuropathy, neutropenia, arthralgia, and myalgia but more thrombocytopenia and anemia in patients with advanced NSCLC (Socinski et al. J Clin Oncol. 2012;30:2055-2062). We hypothesized that these differences might lead to differences in the cumulative dose received and regimen duration in clinical practice.
Methods:
Fully de-identified electronic medical records (EMRs) from October 1, 2012, to September 30, 2014, from a national EMR (OncoEMR; Altos Solutions, Inc) were analyzed. Patients receiving first-line therapy with P every week (P7), P every 3 weeks (P21), or nab-P every week for stage IV NSCLC were identified. The majority of patients also received carboplatin. The total cumulative dose (mg/m[2]), treatment duration, and database persistence (a surrogate for overall survival) for the taxane regimens were determined. Regression and Cox proportional hazards models were used to assess the 3 groups, with the inclusion of age, sex, race, platin use, bevacizumab use, histology, prior adjuvant taxane use, and comorbidities (a total of 11 degrees of freedom) to control for the potentially confounding effects of these variables.
Results:
A total of 475 patients had complete data. 208 patients with NSCLC received P7, 153 received P21, and 114 received nab-P. The total cumulative dose was significantly greater for nab-P (932 mg vs 487 mg for P7 and 695 mg for P21; P < 0.001 for both). The median treatment duration was 104.5 days for nab-P, 69.5 days for P7, and 84.0 days for P21 (P < 0.05 for both). The median database persistence after taxane initiation was significantly longer for nab-P (378 days vs 214 days for P7 and 196 days for P21; P < 0.001 for both).
Conclusion:
Patients with NSCLC treated with nab-P had a longer treatment duration, received a greater cumulative dose, and had longer database persistence than patients treated with P7 or P21.
