Author of

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  P3.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 208)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Treatment of Advanced Diseases - NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 15258

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    P3.01-049 - Concomitant Chemoradiotherapy with Etoposide & Cisplatin versus Docetaxel & Cisplatin in Locally Advanced Non-Small Cell Lung Cancer (ID 1453)

    09:30 - 09:30  |  Author(s): M. Tambas
    • Abstract
    • Slides

    Background:
    There is currently no consensus regarding which chemotherapy regimen is best to administer with radiotherapy in patients with locally advanced non–small-cell lung cancer. Here, our aim was to compare the outcome of patients treated with either etoposide-cisplatin (EP) or docetaxel-cisplatin (DP) in this curative setting.
    
    Methods:
    The patients treated with concurrent radiotherapy with either EP or DP with from 2004 to 2012 were identified. Patients whose medical records and follow up information obtained in details were included to this retrospective study. Survival rates were compared using Cox proportional hazards regression models with adjustments for confounding provided by propensity score methods.
    
    Results:
    A total of 105 patients were treated with concurrent chemoradiotherapy for locally advanced (IIB-IIIA-IIIB) non-small cell lung cancer in Istanbul University, Institute of Oncology between 2004 and 2012. Totally 50 patients (median age 54 yr; 32-70 yr) given concurrent EP and 55 patients (median age 55 yr; 37-73) given concurrent DP were enrolled to analyses. There was no statistically significant difference in baseline clinicopathological features including age, gender, performance status, and weight loss, histological subtype, primary lung side, clinical T, N and TNM stages between 2 groups. In univariate analysis, median overall survival of patients treated with EP was found to be higher than that of patients treated with DP (41 months versus 20 months, p= 0.003). Multivariate analysis further revealed survival advantage with EP as compared to DP (hazard ratio [HR], 0.46; 95% CI, 0.25 to 0.83) (p=0.009). Toxicity profile of 2 treatment groups were found to be similar except that pulmonary toxicity was higher in DP group compared to EP (grade 3-4: 0 versus 6%, p= 0.024).
    
    Conclusion:
    Concurrent chemoradiotherapy with EP may provide more favorable outcome than that of DP with acceptable safety profile.
    
    

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