Author of

• 15209

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  P3.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 208)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Treatment of Advanced Diseases - NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 15254

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    P3.01-045 - Short-Term Outcomes of Stage IV Non-Small Cell Lung Cancer with Brain Metastasis (ID 2701)

    09:30 - 09:30  |  Author(s): S.K. Hwang
    • Abstract

    Background:
    Patients who had non-small cell lung cancer with brain metastasis at the initial diagnosis had poor prognosis and quality of life. We reviewed patients who had undergone lung resection and brain surgery. We also analyzed the characteristics of the patients and the factors affecting survival and recurrence.
    
    Methods:
    Between 2007 and 2012, 25 consecutive patients who had undergone lung resection and brain surgery because of non-small cell lung cancer with brain metastasis were retrospectively evaluated in a single-center. The non-small cell lung cancer subtype was adenocarcinoma in 23 patients, squamous cell carcinoma in 1 patient, and adenosquamous cell carcinoma in 1 patient. Twenty patients underwent Gamma Knife radiosurgery. Nodal stage was stage 0 in 9 patients, stage 1 in 9 patients, and stage 2 in 7 patients.
    
    Results:
    The median survival time after lung resection was 36.8 months. The 1-, 2-, and 3-year survival rates after lung resection were 95.8%, 79.2%, and 54.2%, respectively, and the 1-, 2-, and 3-year disease-free survival rates were 95.8%, 82.9%, and 64.2%, respectively. There were no local recurrences. Brain surgery methods did not affect disease-free survival (p=0.201) or overall survival (p=0.567). Nodal stage also did not affect disease-free survival (p=0.519) or overall survival (p=0.645).
    
    Conclusion:
    Even in cases of stage IV non-small cell lung cancer with brain metastasis, assertive lung resection and brain surgery bring improvements of survival and recurrence to patients. Brain surgery methods do not affect survival or recurrence. Therefore, Gamma Knife radiosurgery is a good choice for quality of life for patients.