Author of

• 15209

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  P3.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 208)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Treatment of Advanced Diseases - NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 15251

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    P3.01-042 - Neutrophilia and Lymphopenia Can Be Prognostic Factors in Non-Small Cell Lung Cancer with Adenocarcinoma Histology (ID 2490)

    09:30 - 09:30  |  Author(s): S. Kim
    • Abstract
    • Slides

    Background:
    Neutrophil count is associated with prognosis in some cancers. Direct cell-cell interactions between neutrophils and tumor cells enhance tumor growth in Non-small cell lung cancer (NSCLC). We planned to identify clinical and laboratory factors including neutrophil and lymphocyte counts that can be used to estimate the overall survival.
    
    Methods:
    We retrospectively reviewed 60 patients with advanced or recurrent NSCLC with adenocarcinoma histology diagnosed between 2009 and 2013. We performed univariate and multivariate stepwise Cox regression analyses to identify survival prognostic factors.
    
    Results:
    Median survival time was 18.0 months (95% CI; 13.8 – 22.2 months). Median age was 64.5 years old. Sixteen patients (26.7%) were current smoker, sixteen patients (26.6%) were past smokers and 28 patients (46.7%) were non-smokers. Forty three patients’ ECOG PS was 0 or 1 and remaining seventeen patients’ ECOG PS was 2. Number of metastatic sites was less than four in the forty four patients and remaining sixteen patients have more than four metastatic sites. In univariate analysis, seven factors were identified: Loss of appetite (HR, 0.344), brain metastasis (HR, 0.444), metastasis in other organs (HR, 2.886), WBC count (HR, 3), neutrophil count (HR, 2.322), lymphocyte count (HR, 0.431), neutrophil lymphocyte ratio (HR, 2.322). In multivariate analysis, two independent prognostic factors were identified: neutrophil count (HR, 2.418), lymphocyte count (HR, 0.414).
    
    Conclusion:
    Increase of neutrophil count and decrease of lymphocyte count can be used to predict survival in advanced or recurrent non-small cell lung cancer patients with adenocarcinoma histology.
    
    

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