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J. Li



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    P3.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 208)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Advanced Diseases - NSCLC
    • Presentations: 1
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      P3.01-024 - The Effect of Pemetrexed as First Line Chemotherapy in Advanced Non-Small-Cell Lung Cancer with Anaplastic Lymphoma Kinase Gene Rearrangements (ID 1179)

      09:30 - 09:30  |  Author(s): J. Li

      • Abstract
      • Slides

      Background:
      The efficacy of pemetrexed-based first-line chemotherapy in ALK-positive NSCLC has been documented in several studies. More data for Chinese population are still needed.

      Methods:
      We retrospectively reviewed the chart of 34 patients with ALK-positive advanced NSCLC. All of them had received pemetrexed as the first-line chemotherapy in our hospital from May 2011 to October 2014. We analyzed the clinical characteristics and treatment outcomes of these patients.The primary end points were response rate and progression-free survival.

      Results:
      The median age was 52 years (range from 34 to 76) and 58.8% (20/34) of the patients were never smokers. All tumors were adenocarcinoma. There were two cases harboring ALK translocation and EGFR mutation. Pemetrexed combined with platinum was administered in the first-line setting and the median treatment cycle was 4.5. The median progression-free survival (PFS) of ALK-positive patients was 8.8 months (95%CI 7.397-10.213). At the time of analysis, 7 with PR (20.6%)，23 with SD (67.6%)，4 with PD (11.8%) and no CR achieved. The objective response rate was 20.6% (7/34)，and the disease control rate was 88.2% (30/34). Common adverse events with pemetrexed were neutropenia (52.9%)，nausea (58.8%)，transaminase elevation (29.4%) and fatigue (9.3%)，mainly in grade 1 or 2.

      Conclusion:
      Pemetrexed is efficient and well tolerated as first-line treatment for ALK-positive NSCLC in Chinese population. Thus, pemetrexed might provide an alternative option for the treatment of ALK-positive lung adenocarcinoma.

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