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S. Yu



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    P3.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 208)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Advanced Diseases - NSCLC
    • Presentations: 1
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      P3.01-002 - PD-L1 Expression and FGFR1 Amplification in Chinese Stage III/IV Lung Squamous Carcinoma (ID 2478)

      09:30 - 09:30  |  Author(s): S. Yu

      • Abstract
      • Slides

      Background:
      This study aims to explore status of PD-L1 expression and FGFR1 amplification in stage IIIB/IV SQC, further to analyze their correlation with clinicpothological characteristics, efficacy of gemcitabine based chemotherapy and prognosis of SQC patients.

      Methods:
      128 stage III/IV SQC patients were enrolled into this study from May 1[st] 2009 to May 31[st] 2014, all of which had complete clinical profile. 78 patients received gemcitabine-based chemotherapy. Immunohistochemistry (IHC) was used to detect PD-L1 expression, fluorescence in situ hybridization was applied to detect FGFR1 amplification. SPSS17.0 was used for statistical analysis.

      Results:
      80 (62.5%) SQC had IHC positive PD-L1 expression. PD-L1expression was significantly higher in male and smoker population than female and non-smoker, respectively. (gender: 65.5% VS. 22.2%, P=0.011; smoke histology 67.0% VS. 44.0%, P=0.039). PD-L1 expression had no significant relationship with objective response rate (ORR) and disease control rate(DCR) for gemcitabine-based chemotherapy(54.8% VS.59.7%, P =0.434 and P=0.840). However, the overall survival (OS) of PD-L1 negative SQC was significantly longer than PD-L1 positive group (29.8 vs. 20.1 months, P=0.001). 32 cases showed FGFR1 FISH positive (32/128, 25.0%), and stage III patients presented lower rate compared with stage IV SQC (17.1% vs. 36.5%, P=0.013). FGFR1 amplification had no relationship with ORR and DCR in patients treated with gemcitabine-base chemotherapy(32.3% VS.30.6%. P=0.663 and P=0.659). No correlation between PD-L1 expression and FGFR1 amplification was found (P=0.916).

      Conclusion:
      PD-L1 expression could act as a prognosis factor in Chinese stage III/IV SQC patients. PD-L1 expression and FGFR1 amplification might be irrelevant.

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