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• 14704

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  P2.11 - Poster Session/ Palliative and Supportive Care (ID 230)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Palliative and Supportive Care
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14717

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    P2.11-013 - Prognostic Factors Associated with Overall Survival in Croatian Patients with Advanced Lung Cancer (ID 1644)

    09:30 - 09:30  |  Author(s): D. Trivanovic
    • Abstract
    • Slides

    Background:
    In Croatian population Lung cancer (LC) is the most common cancer in male and third most common in women. The age-adjusted incidence rates are 63.5 per 100,000 populations per year. The aim of this study was to investigate the prognostic factors associated with overall survival in patients with cytological and/or histological confirmed advanced (IIIA-IV stage) LC.
    
    Methods:
    In this single institution prospective study, 164 consecutive patients were included between September 2008 and January 2013 from Istrian County, Croatia.The prognostic factors evaluated for 2-year overall survival including gender, age, performance status, histology, blood group type, location od tumor, metastatic sites, anemia, elevated WBC, platelets, and diabetes mellitus. All factors with a P value < 0.05 at univariate analysis were entered into a multivariate analysis using Cox proportional-hazards models.
    
    Results:
    The median age of patients was 64.0 years (range 36 – 85 years) with males predominance (115 males vs. 49 females). The histological types included: adenocarcinoma 56 (34%), squamous cell carcinoma 50 (30%), small cell carcinoma 33 (20%) other or not-otherwise specified 25 (16%). The median follow-up time was 14.1 months. The 2-year overall survival rate of 164 patients was 27.0%. Female gender and non liver metastatic disease are significantly associated with better overall survival. Data were shown in Table 1. Cox Regression analysis adjusted to tumor stage and age demonstrated that patients with 0 type blood group in adenocarcinoma subpopulation present a worst overall survival when compared to other blood type groups. Not elevated serum platelets in squamous NSCLC and elevated WBC, and female gender are independent prognostic factors in SCLC. Table 1 Significant prognostic factors for overall survival in NSCLC

    Baseline prognostic factor	Univariate analysis	Multivariate analysis		2-year survival rate %
    	P-value	HR (95% CI)	P-value
    Female* vs Male	0.020	0.62 (0,41-0.93)	0.022	38.0
    Non-liver metastasis	0.024	0.60 (0.39-0.95)	0.028	28.8
    0 blood group in adenocarcinoma NSCLC	0.008	6.64 (1.38-32.14)	0.019	18.7
    Normal serum platelets level	0.013	1.27 (0,45-3.59)	0.654	23
    Female* vs Male gender in SCLC	0.01	0.30 (0.11-0.82)	0.019	44
    Non-liver metastasis in SCLC	0.027	0.43 (0.18-1.01)	0.055	20
    Elevated serum WBC	0.015	0.39 (0.17-0.90)	0.026	19

    Abbrevations: *referent, NSCL=Non Small Cell Lung Cancer, SCLC= Small Cell Lung Cancer, WBC= White Blood Cells
    
    Conclusion:
    Our results indicated that female gender is powerfull favorable prognostic factor in NSCLC and SCLC. 0-type blood group is significant prognostic factor for short term survival following diagnosis of advanced lung adenocarcinoma and elevated WBC is associated with longer survival in SCLC subpopulation of advanced disease.
    
    

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