Virtual Library
Start Your Search
T. Shigenobu
Author of
-
+
P2.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 225)
- Event: WCLC 2015
- Type: Poster
- Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
-
+
P2.08-032 - Multimodality Treatment for Advanced Thymoma (ID 2589)
09:30 - 09:30 | Author(s): T. Shigenobu
- Abstract
Background:
Surgery remains the center of treatment of resectable thymoma. Radiation and chemotherapy have been applied widely as adjuvant treatment. However, the optimal treatment strategy for advanced thymoma remains controversial. This study aimed to evaluate the efficacy of multimodal treatment for patients with advanced stage III, IV thymoma.
Methods:
A total 250 consecutive patients with thymoma were treated in our hospital from January 1985 to December 2013. Among these, 70 patients were staged as Ⅲ and Ⅳ. The overall survival (OS) was analyzed according to clinicopathological factors and types of treatment.
Results:
There were 32 patients with stage III (46%), 35 patients with IVa (50%), and 3 patients with IVb (4%). The 10-year OS rates of patients with III+IV, III, IVa were 76%, 89%, and 64%, respectively. Types of treatment were as follows: surgery alone in 23 patients (33%), surgery followed by radiation in 31 (44%), surgery followed by chemotherapy in 2 (3%), surgery followed by chemo-radio therapy in 8 (11%), chemo-radio therapy alone in 6 (9%). There was no significant difference in OS among the treatment groups. Twenty-eight (40%) patients coexisted with myasthenia gravis (MG). There were no differences in OS between those with and without MG. Significant difference in OS was observed between 49 patients who underwent R0/R1 resection and 21 patients who underwent R2 resection (P = 0.004). The disease-free survival was worse in patients with combined full-dose mediastinal and low-dose, entire thoracic radiation than in those with full-dose mediastinal radiation alone (P = 0.04).
Conclusion:
In this retrospective study, it was shown that the surgical resection should always try to leave no gross tumor behind to ensure better prognosis. Although the future comparative, prospective study seems difficult because of the limited number of new cases, the multimodal approach with maximal treatment intensity looks promising.
