Author of

• 14661

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  P2.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 225)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14688

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    P2.08-027 - Investigation for the Optimum Resectable Pathological Size of Small Solitary Metastasis from Colorectal Cancers (ID 731)

    09:30 - 09:30  |  Author(s): Y. Sakao
    • Abstract

    Background:
    Surgery is still standard modality for the patients with pulmonary metastases from colorectal cancer in spite of recent remarkable development of chemotherapy. The aim of this multi-institutional retrospective study was to determine which pathological size is the best suited to pulmonary resection, and to evaluate the prognostic factors in the patients with small colorectal solitary metastasis.
    
    Methods:
    Patients and Methods Patients with pathologically solitary metastasis were recruited. The retrospective examined sample size was finally 561 who underwent complete resection at 46 facilities in Japan from 2004 to 2009.
    
    Results:
    No statistically significant difference was detected between with adjuvant chemotherapy and without in disease free survival (DFS) and overall survival (OS) (p=0.09 and p=0.79). Disease free survival (DFS) and overall survival (OS) calculated after initial pulmonary resection at 5 years were 71.0% and 41.7%, respectively. Tumors from 8-15mm in diameter showed the lowest incidence of recurrence in this series. Especially, relapse was occurred in all patients with pathological size 5mm (7/7, 100%) among the smallest group in the course of a median 279 days. Although significant difference was not found, a tendency was recognized with 15mm as the border by the recurrence proportion and the receiver operating characteristic curves for DFS. CEA abnormality, pathological size (more than 20 mm), and Disease free interval (more than 2 years) were the prognostic factors for DFS, whereas age (more than 70 years old), CEA abnormality, DFI (more than 2 years), and previous extrapulmonary treatment were the prognostic factors for OS in both univariate and multivariate analyses.
    
    Conclusion:
    Our multi-institutional retrospective study proposed that the optimum pathological size up to 15 mm was suitable to pulmonary resection in the patients with solitary metastasis from colorectal cancers, but the smallest nodules (less than 7 mm) had a possibility of re-recurrence within a median one year.