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R. Gaafar
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P2.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 225)
- Event: WCLC 2015
- Type: Poster
- Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.08-025 - Contributing Factors to the Outcome of Primary Malignant Chest Wall Tumors (ID 611)
09:30 - 09:30 | Author(s): R. Gaafar
- Abstract
Background:
Primary malignant chest wall tumors are a heterogeneous group of tumors. They require special experience in designing resection and reconstruction. They account for less than 1% of all primary malignant tumors. This study is designed to clarify different factors contributing to the outcome of patients with primary malignant chest wall tumors in our institution.
Methods:
A retrospective study included 97 patients with pathology proven primary malignant chest wall tumors, treated at the national cancer institute, Cairo University, Egypt, during the period from 2002 to 2012. Computed tomography scan of the chest and upper abdomen was considered the primary staging tool for all patients. Magnetic resonance imaging was requested whenever indicated. Surgical resection and reconstruction was designed according to the site and extent of the lesion. resected. Adjuvant and neo-adjuvant therapy was given according to thoracic oncology committee decision. This study was approved by the ethical committee of our institution and informed patient consent was taken.
Results:
Primary malignant chest wall tumors represented 10.5% of all thoracic malignanciesin our institution. There were 46 males and 51 females, the median age was 41 years. Chondrosarcoma was the commonest tumor histology (20.6%). The mean tumor size was 9.3x6.2cm. Tumor multiplicity was found in 15.4% of patients. Bone resection was performed in 76 patients (78.3%), ribs resection was performed in 62 patients and the average number of resected ribs per patient was 2.57 ribs. Sternal resection was done in 9 patients. R0 resection was achieved in 73% of patients. There was one operative related mortality and 23% of patients suffered procedure related complications. Local recurrence developed in 45.3% of patients. The overall survival for the whole group at 1, 3 and 5 years was 67.1%, 37.2% and 26.1 % respectively and the median survival time was 26 months. Different prognostic variables were used to assess better survival including : age , sex, site , size pathologic subtype , tumor grade,, safety margin Good prognostic factors include female sex, age ≤ 40years, no rib resection, safety margin ≥ 1cm, when the least safety margin involve the soft tissue and not the bone, tumor size ≤ 6cm in diameter.
Conclusion:
rimary malignant chest wall tumors should be treated with highly qualified thoracic surgeon and achieving wide resection margins is of great importance to minimize local tumor recurrence that will have an impact on long-term survival.
