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F.Y. Bhora
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P2.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 225)
- Event: WCLC 2015
- Type: Poster
- Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.08-017 - Chest Wall Soft Tissue Sarcomas: Impact of Adjuvant Radiation Therapy Following Surgical Resection (ID 1587)
09:30 - 09:30 | Author(s): F.Y. Bhora
- Abstract
Background:
Primary chest wall soft tissue sarcomas are rare tumors of the thoracic wall. The objective of this study is to evaluate the impact of adjuvant radiation therapy on survival following surgical resection using the Surveillance, Epidemiology, and End Results (SEER) database.
Methods:
We queried the SEER database for all surgically resected histologically proven primary chest wall soft tissue sarcomas between 1998 and 2010. Exclusion criteria included pediatric sarcomas, multiple malignancies and unknown grade, stage or radiation therapy status. Chi-square tests were performed to identify covariates associated with receiving adjuvant radiation therapy. Coarsened-exact matching was used to generate a matched cohort of patients who received adjuvant radiation following surgery and patients who underwent surgery alone. Cox regression and Kaplan-Meier analyses were performed to determine covariates associated with overall survival.
Results:
A total of 570 patients were included in the cohort prior to matching based on the selection criteria. Histological type (p = 0.003) and tumor grade (p < 0.001) were independently associated with receiving radiation therapy. Cox-regression did not demonstrate reduced hazards of death for adjuvant RT. After coarsened-exact matching, Kaplan-Meier survival analysis of matched groups (105 surgery alone and 104 surgery + RT) showed significant 1-, 3- and 5-year overall survival difference (p = 0.034) in surgery + RT compared to surgery alone.
Conclusion:
In a matched large population cohort, adjuvant radiation therapy appears to improve overall survival following surgical resection of chest wall soft tissue sarcomas. Further trials are required to determine the efficacy of adjuvant radiation therapy in this population.Figure 1
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-005 - Third Primary Lung Cancers: Incidence and Benefits of Surgical Therapy (ID 1688)
09:30 - 09:30 | Author(s): F.Y. Bhora
- Abstract
Background:
Continued surveillance of lung cancer patients after curative surgery allows for the diagnosis of new disease. However, there is a relative paucity of data in regards to the development of third primary lung cancers. The goals of this study were to examine the incidence of third primary cancers and the results of surgical therapy.
Methods:
Surgically resected Stage 1 second primary lung cancers with complete data were identified in The Survival Epidemiology and End Results (SEER) database between 2004 and 2010. Among these 238 cases, those which developed a third primary lung cancer 6 or more months after the diagnosis of the second primary were analyzed. Statistical methods were performed using Kaplan-Meier and multivariate analysis. A p value < 0.05 was considered statistically considered significant.
Results:
Twenty-four patients (10.1%) experienced a third primary lung cancer; sixteen cases (66.7%) were diagnosed in stage I. Twelve patients (50% of cases) underwent cancer surgery. Nine patients (37.5%) were treated with beam radiation – alone (8 cases, 89%) or in combination with surgery (1 case, 11%). Surgery was performed more frequently in early stages (75% of surgical cases were stage I versus 58% of non-surgical cases). There was no difference in age between patients who underwent any treatment and those who did not. Length of follow-up in third primary cancers was 18 months if surgically treated and 8 months if not surgically treated (p < 0.02). At multivariate analysis, the only independent predictor of improved survival was treatment (Hazard ratio (HR) 0.21, 95% CI: 0.07-0.66; p=0.007). Both surgery (HR=0.02; 95% CI: 0.002-0.29) and radiation (HR= 0.04; 95% CI: 0.002-0.54) significantly improved survival. Figure 1
Conclusion:
The overall incidence of third primary lung cancers after a second primary is 10.1%. Surveillance and intervention at early stage results in improved survival.
