Author of

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  P2.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 225)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14678

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    P2.08-017 - Chest Wall Soft Tissue Sarcomas: Impact of Adjuvant Radiation Therapy Following Surgical Resection (ID 1587)

    09:30 - 09:30  |  Author(s): A.M. Al-Ayoubi
    • Abstract
    • Slides

    Background:
    Primary chest wall soft tissue sarcomas are rare tumors of the thoracic wall. The objective of this study is to evaluate the impact of adjuvant radiation therapy on survival following surgical resection using the Surveillance, Epidemiology, and End Results (SEER) database.
    
    Methods:
    We queried the SEER database for all surgically resected histologically proven primary chest wall soft tissue sarcomas between 1998 and 2010. Exclusion criteria included pediatric sarcomas, multiple malignancies and unknown grade, stage or radiation therapy status. Chi-square tests were performed to identify covariates associated with receiving adjuvant radiation therapy. Coarsened-exact matching was used to generate a matched cohort of patients who received adjuvant radiation following surgery and patients who underwent surgery alone. Cox regression and Kaplan-Meier analyses were performed to determine covariates associated with overall survival.
    
    Results:
    A total of 570 patients were included in the cohort prior to matching based on the selection criteria. Histological type (p = 0.003) and tumor grade (p < 0.001) were independently associated with receiving radiation therapy. Cox-regression did not demonstrate reduced hazards of death for adjuvant RT. After coarsened-exact matching, Kaplan-Meier survival analysis of matched groups (105 surgery alone and 104 surgery + RT) showed significant 1-, 3- and 5-year overall survival difference (p = 0.034) in surgery + RT compared to surgery alone.
    
    Conclusion:
    In a matched large population cohort, adjuvant radiation therapy appears to improve overall survival following surgical resection of chest wall soft tissue sarcomas. Further trials are required to determine the efficacy of adjuvant radiation therapy in this population.Figure 1
    
    
    
    

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