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N. Mosalam
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P2.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 225)
- Event: WCLC 2015
- Type: Poster
- Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.08-009 - Malignant Pleural Mesothelioma: A Retrospective Analysis of Clinicopathological and Survival Data in Egyptian Patients (ID 2546)
09:30 - 09:30 | Author(s): N. Mosalam
- Abstract
Background:
The incidence of Malignant pleural mesothelioma ( MPM) in Egypt showing a steady increase which mandate more intension. This study was conducted to study the clinico-epidemiological data and different treatment modalities offered for (MPM) patients and to evaluate their impact on survival
Methods:
Data was retrospectively collected from the medical files of 103 cases presented as MPM to Department of Clinical Oncology and Nuclear Medicine, Ain Shams University Hospitals from January 2011 to December 2013. Demographics, risk factors, morphological status and treatment received were described using frequencies. Survival outcome was described using Kaplan Meier curves stratified according to morphology and treatment received.
Results:
A steady increase in the number of cases was detected, from 30 in 2011 and 40 cases in 2013. Male/female ratio was 0.98 (p = 0.989). The median age was 58 years (range 28-85). About 60 patients (58.3 %) came from endemic areas. Only one patient underwent decortication surgery. About 70.9 %, 21.4 % and 5.8% of the patients received chemotherapy (CT) in 1[st] line, 2[nd] line and 3[rd] line respectively and median OS was 5 months (Range 1-48). Only 5.5%, 21.7% and 33.3% of the patients received Pemetrexed in 1[st] line, 2[nd] line and 3[rd] line CT respectively.Kaplan-Meier survival for sex, age, residence and the pathological types was insignificant. The median survival for epithelial versus non-epithelial pathological types was 6 and 5 months respectively (P= 0.165).The median survival for the patients who received 1[st] line, 2[nd] line and 3[rd] line CT versus best supportive care (BSC) was 3 and 8 months (P = 0.001), 12 and 5 months (P < 0.001) and 12 and 5 months (P =0.417) respectively.There was a significant difference (P = 0.001) between the median survival for patients who received CT (8 months, 95% CI 5.422-10.578) and those who were offered BSC ( 3 months, 95% CI 1.715-4.285). Another factor that affected the survival negatively was non-platinum based CT in the 1[st] line (2 months versus 9 months P =0.001). Cox regression analysis revealed that the factors that predicted better OS were patients being offered CT rather than BSC especially patients who received 1[st] and 2[nd] line of CT (P =0.004).
Conclusion:
MPM is a growing health burden in Egypt which is underestimated and need more support to offer new treatment modalities. The CT prolongs survival compared to BSC in patients with MPM. Moreover, using platinum based CT provides survival advantages.
