Author of

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  P2.07 - Poster Session/ Small Cell Lung Cancer (ID 222)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Small Cell Lung Cancer
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14660

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    P2.07-018 - The Association of Hyponatremia with the Prognosis of Patients with SCLC (ID 45)

    09:30 - 09:30  |  Author(s): K. Yue
    • Abstract
    • Slides

    Background:
    Lung cancer is still one of the leading causes of cancer patients,which has a high incidence and poor prognosis. Hyponatremia is found in about 15% patients with small cell lung cancer(SCLC) at different disease stages. This study aims to analyze the association of hyponatremia with the prognosis of patients with SCLC.
    
    Methods:
    The clinical materials of 489 patients with SCLC treated in ZheJiang cancer hospital between January 2010 and December 2012 were retrospectively analyzed. Kaplan- Meier and Log-Rank test were used to analyze the data. Prognostic factors were analyzed by multivariate Cox proportional hazards model.
    
    Results:
    Hyponatremia occurred in 17.9%、13.3%、12.5% and 18.9% patients at 4 different clinical stages(before treatment, after 2 cycles of chemotheropy, after radiotheropy and after all the treatments). The serum sodium level was not significantly different among patients of different gender, age, BMI, KPS, hypertension and diabetes mellitus history, tumor stage, smoking history and tumor metastasis (P>0.05). Univariate analysis showed that hyponatremia significantly affected the survival of patients. Multivariate analysis showed that hyponatremia was the independent prognostic factor for SCLC. The relative risk of death of patients with hyponatremia was elevated by 1.297 times (95%CI:1.160~1.449，P<0.001), 1.366 times (95%CI:1.023~1.825,P=0.035), 1.77 times (95%CI:1.168~2.682,P=0.007) and 1.507 times (95%CI:1.167~1.944,P=0.002).
    
    Conclusion:
    Hyponatremia is an independent prognostic indicator for the survival of initially treated patients with small cell lung cancer(SCLC).
    
    

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