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Y.S. Kim
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P2.07 - Poster Session/ Small Cell Lung Cancer (ID 222)
- Event: WCLC 2015
- Type: Poster
- Track: Small Cell Lung Cancer
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.07-017 - Body Composition Analysis Using Computed Tomography in Patients with Small Cell Lung Cancer (ID 2542)
09:30 - 09:30 | Author(s): Y.S. Kim
- Abstract
Background:
Although the clinical significance of body composition has been recognized as associated with performance status and prognoses for solid tumors, no study has specifically evaluated baseline body composition in detail using computed tomography (CT) images for patients with small cell lung cancer (SCLC).
Methods:
We analyzed skeletal muscle mass and fat mass in 150 patients with pathologically proven SCLC between January 2010 and November 2014 in our institution. Cross-sectional areas of skeletal muscle (Hounsfield unit, HU ranges -29 to 150) and fat tissue (HU, -190 to -30) were measured on the level of 3rd lumbar vertebra using the baseline CT images. Data on clinical characteristics were retrospectively collected.
Results:
Mean age was 69 ± 9 years (85.3% were male). At the time of diagnosis, mean body mass index (BMI) was 22.1, with 40.7% of patients being overweight or obese (BMI ≥ 23). Only 16.7% overall were underweight as conventionally understood (BMI < 18.5). The overall prevalence of severe muscle depletion (sarcopenia) was 53.3% and was present in patients in all BMI categories (84.0% in underweight patients, 45.2% in overweight and obese patients). A much higher proportion of men (60.2%) than women (13.6%) met the criteria of sarcopenia.
Conclusion:
Wasting of skeletal muscle is a prominent feature of patients with small cell lung cancer, despite normal or heavy body weights.
