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M. Zhang
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P2.07 - Poster Session/ Small Cell Lung Cancer (ID 222)
- Event: WCLC 2015
- Type: Poster
- Track: Small Cell Lung Cancer
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.07-006 - Study on Feasibility of Hippocampal Avoidance Prophylactic Cranial Irradiation (ID 1474)
09:30 - 09:30 | Author(s): M. Zhang
- Abstract
Background:
To investigate the dosimetric characteristics, feasibility and risk of Hippocampal avoidance prophylactic cranial irradiation (HA-PCI), in intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT).
Methods:
Sixteen patients with limited-stage small-cell lung cancer (LS-SCLC) achieved complete remission after chemoradiotherapy accepted HA-PCI. After image evaluation by fusing CT and MRI, hippocampal avoidance regions were created in the hippocampus. A 5 mm area around the hippocampus was plotted as radiation dose deduction area. Patients were randomly assigned to accept intensity-modulated radiotherapy (IMRT) or volumetric modulated arc therapy (VMAT). The prescription dose was DT25Gy per 10 fractions.The dose distribution of whole brain, hippocampus and hippocampal plus 5mm were calculated.
Results:
The mean value of Hippocampal volume in the sixteen patients was 2.76 cm[3](range 2.56cm[3]-3.01cm[3]). Using IMRT and VMAT, the mean value of radiation dosein hippocampus was 9.04Gy (range 8.92Gy-9.39Gy)and 10.32Gy (range 10.13Gy-10.82Gy), respectively, reduced by 66.03% and 61.17% compared with whole-brainirradiation.The mean dose in the avoidance regions for IMRT and VMAT was 13.57Gy (range 13.47Gy-13.67Gy),and 14.86Gy (range 14.33Gy-15.89Gy), respectively, reduced by 49.00% and 44.29% compare with whole-brain radiation.
Conclusion:
HA-PCI in IMRT and VMAT is feasible in clinical practice and can achieve adequate whole brain coverage, as well as reduce exposure dose in hippocampus. HS-PCI can protect patient's neurocognitive function.
