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Y. Shiraishi
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P2.05 - Poster Session/ Prevention and Tobacco Control (ID 216)
- Event: WCLC 2015
- Type: Poster
- Track: Prevention and Tobacco Control
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.05-010 - The Chronic Respiratory Infection as a Background of the Lung Cancers (ID 2636)
09:30 - 09:30 | Author(s): Y. Shiraishi
- Abstract
Background:
It had been pointed out about the respiratory infectious disease that the tuberculosis patients had increased risk of lung cancers, and the lung cancer patients had increased risk of tuberculous infection. In recent years, primary lung cancer cases are increased, despite of decreasing of tuberculosis infection and, on the other hand, of increasing of chronic respiratory infectious diseases such as the pulmonary non-tuberculous mycobacteriosis or mycosis. A purpose of this study is to research the chronic respiratory infectious diseases as a background of the lung cancer treatment.
Methods:
From January, 2010 to December, 2014, 431 cases of radical operations for primary lung cancers were performed in our institute. A bacteriological search by the expectoration and bronchus absorption sputum was examined in 389 cases preoperatively. Among these cases, we retrospectively researched about the fungal infections and mycobacterial infections.
Results:
Among the 431 primary lung cancer cases, 19 cases of fungal infections were detected, 12 cases of non-tuberculous mycobacterium infections were detected, four were co-existing and none was tuberculosis. In the patient background of mycosis, gender was 15 cases of male and four of female, the mean age was 69.7±8.1 years old (53-88 years old), and mean smoking index was 1073 (0-2640). The histological types of the lung cancers were eight cases of squamous cell carcinoma, seven of adenocarcinoma, each one of small cell lung cancer, pleomorphic carcinoma and LCNEC. The pathological stages of the lung cancers were nine cases of stage I, five of stage II, four of stage III and two of stage IV. The detected species of bacteria were nine cases of Candida spp., eight of Candida albicans, two of Aspergillus fumigatus and one of Aspergillus niger. The patients had past history of tuberculosis in three cases, cancer in four, diabetes in 6 and continuous treatment by steroid in two. In the patient background of non-tuberculous mycobacteriosis, gender was 7 cases of male and 5 of female, the mean age was 71.7±10.2 years old (50-88 years old), and mean smoking index was 556 (0-1800). The histological types of the lung cancers were six cases of adenocarcinoma, three of LCNEC, two of squamous cell carcinoma, one of small cell lung cancer. The pathological stages of the lung cancers were eight cases of stage I, one of stage II, two of stage III and one of stage IV. The detected species of bacteria were 11 cases of Mycobacterium avium complex and one of Mycobacterium mucogenicum. The patients had past history of cancer in two cases and continuous treatment by steroid in two, but none of tuberculosis and diabetes. The five year survival rate of the lung cancer cases with the chronic respiratory infections was 63.0% and that without the chronic respiratory infections was 76.6%. The lung cancer cases with chronic respiratory infections showed tendency of poor prognosis, although there was no significant difference between two groups (p=0.087).
Conclusion:
The lung cancer cases with chronic respiratory infections had past history of coexisting disease, and showed tendency of poor prognosis.
