Author of

• 14600

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  P2.05 - Poster Session/ Prevention and Tobacco Control (ID 216)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Prevention and Tobacco Control
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14606

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    P2.05-006 - Meta-Analysis of Radon Indoor Concentrations and Risk of Lung Cancer (ID 2519)

    09:30 - 09:30  |  Author(s): L.E. Mendes
    • Abstract

    Background:
    Our ongoing research is assessing stem cells alterations in cancer due to indoor radon exposure. Therefore, we performed a meta-analysis of previous studies on radon exposure and lung cancer to evaluate the strength of the statistical and radon-detection methods for determining exposure-response risk levels.
    
    Methods:
    Literature search used PubMed. Inclusion criteria: a), original case-control studies; b), use of alpha track detectors; c), report weighted average values of radon concentrations over time and/or cumulative exposure rates; d), include only lung cancer diagnosis by pathology and/or imaging; e), frequency-matched controls by age, gender and smoking status; f), enough samples and data for odds ratio estimation and variations; g), published in English. Data Extraction: Statistical data extracted from the selected studies. Studies selected were stratified by level of exposure to evaluate the dose-response relationships. Adjusted odds ratios (CI 95%) extracted for radon concentrations expressed in Bq/m[-3]). All data was later adjusted to WHO’s categories 0-99, 100-199, 200-299 and >300 Bq/m[-3]. Meta-analysis: For each study, analysis of the weighted linear regression of log-adjusted odds ratio was performed according to the average radon concentrations. Coefficients and 95% confidence intervals were calculated according to the various levels of radon concentration. Sensitivity analyzes: Separate meta-analysis was performed by grouping studies with similar characteristics
    
    Results:
    The log-OR for lung cancer risk was 1.22 higher at radon indoor levels >Bq/100[-3], being such levels more frequent in the homes of lung cancer cases. As for smokers, the 1.14 metanalytical measure indicates a log-OR of 3.19 (CI: 95%).
    
    Conclusion:
    This meta-analysis suggests a statistical significant higher risk of lung cancer in individuals exposed to indoor radon levels >Bq/100-3.