Author of

• 14490

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  P2.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 234)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Biology, Pathology, and Molecular Testing
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14569

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    P2.04-079 - Targeting Antigen Presentation by Tumor Infiltrating B Cells to CD4 T Cells in Non-Small Cell Lung Cancer Patient Tumors (ID 3241)

    09:30 - 09:30  |  Author(s): D. Munson
    • Abstract
    • Slides

    Background:
    B cells in tumors (TIL-Bs) are detected in non-small cell lung cancer (NSCLC) and their frequency correlates with improved survival, however, the functional mechanism of TIL-Bs in solid tumors is not well understood. We hypothesize that TIL-Bs help generate potent, long-term immune responses against cancer by presenting tumor antigens to CD4 tumor infiltrating lymphocytes (TILs) in primary human lung tumors.
    
    Methods:
    not applicable
    
    Results:
    Using un-manipulated, primary human B cells from fresh tumor, tumor-adjacent, and normal (cancer-free) lung tissue we observed that the total number of B cells at the site of the tumor versus the tumor-adjacent tissue was increased compared to other immune subsets. Further, in analyzing B cell markers of activation and exhaustion, we observed a spectrum of activation of TIL-Bs. Finally, we showed that TIL-Bs present autologous tumor antigens to CD4 TILs in a subset of NSCLC patients, and that depending on the activation or exhaustion profile of the TIL-Bs, differentiate CD4 TILs to T regulatory cells (Treg). These data suggest that some patients with TIL-Bs have differential function that is influenced by their activation or exhaustion phenotype.
    
    Conclusion:
    In conclusion, the anti-tumor functon of TIL-Bs can be stimulated in some NSCLC patients, and TIL-Bs that cannot be stimulated have increased immune exhaustion and promote Treg differentiation. Ultimately, results from this study will help predict which TIL-B functions to target in future TIL-B-specific immunotherapies or in combination with current immunotherapies for NSCLC patients like blockade of the inhibitory receptor, PD-1.
    
    

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