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Y.W. Yao
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P2.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 234)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.04-031 - EGFR Mutation Associated with Histologic Subtype According to the IASLC/ATS/ERS Adenocarcinoma Classification: A Meta-Analysis (ID 1137)
09:30 - 09:30 | Author(s): Y.W. Yao
- Abstract
Background:
In 2011, the International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society (IASLC/ATS/ERS) proposed the new lung adenocarcinoma histologic classification. The purpose of this meta-analysis is to determine the relationship between EGFR mutation states and different predominant histologic subtypes.
Methods:
We carried out a comprehensive search for published articles from 2011 to February, 2015, using the PubMed, EMBASE databases and Cochrane Library. The main key words used for search were : IASLC/ATS/ERS, new lung adenocarcinoma classification, EGFR. By searching the databases and further checking the reference lists of the publications, we obtained the initial articles. Next, we performed the preliminary screening through reading the titles and abstracts and excluded the obviously irrelevant articles. Then, we downloaded the full texts and read these articles intensively, excluding articles not giving the detailed data for meta-analysis. We extracted information from all eligible studies as follows: author, publish year, region, total cases, mean age, number of a certain histologic subtype, number of EGFR mutation in certain histologic subtype, total number of other histologic subtypes, total number of EGFR mutation in other histologic subtypes. This meta-analysis was completed using the Stata software (version 11.0; StataCorp LP, College Station, TX, USA). Detailed numbers in each included study were pooled to evaluate the association between EGFR mutation and histologic subtype. A random-effect model was used to calculate the pooled relative risks (RRs), 95% confidence interval (95%CI), and P values. Two-sided P values less than 0.05(P<0.05) were considered statistically significant.
Results:
The micropapillary predominant subtype was found to be tended with EGFR mutation (RR=1.37, 95%CI=1.08-1.74, p=0.011). On the contrary, the solid predominant subtype has a low EGFR mutation frequency (RR=0.74, 95%CI=0.59-0.93, p=0.009). Obvious correlation with EGFR mutation states is not found among other histologic subtypes.
Conclusion:
Taken together, the new IASLC/ATS/ERS lung adenocarcinoma classification is a very useful predictor of EGFR mutation frequency, the micropapillary predominant subtype has higher EGFR mutation frequency, on the contrary, the solid predominant subtype with lower frequency.
