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H. Kim
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P2.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 234)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.04-008 - IGF1R Expression Is Predictive of Poor Prognosis in EGFR-Mutant Lung Adenocarcinoma (ID 208)
09:30 - 09:30 | Author(s): H. Kim
- Abstract
Background:
Insulin-like growth factor-1 receptor (IGF1R) is a membrane receptor-type tyrosine kinase that has attracted considerable attention as a potential therapeutic target, although its clinical significance in non-small cell lung cancer (NSCLC) is controversial. This study aimed to clarify the clinical significance of IGF1R expression in human NSCLC.
Methods:
IGFIR protein expression was evaluated by immunohistochemistry in 386 patients with NSCLC who underwent surgical resection (150 squamous cell carcinomas [SqCCs] and 236 adenocarcinomas [ADCs]). Correlations of the expression of IGF1R with clinicopathological and molecular features, and prognostic significance were analyzed.
Results:
Membranous and cytoplasmic IGFIR expression was significantly higher in SqCCs than in ADCs. In patients with SqCC, membranous IGFIR expression was associated with lower cancer stage, and better progression-free survival (PFS) (hazard ratio [HR] = 0.60, 95% confidence interval [CI]: 0.36–0.99, p = 0.045). In patients with ADC, IGFIR expression had no significant prognostic value, but in the subgroup of epidermal growth factor receptor (EGFR)-mutant ADC, membranous IGF1R expression was associated with vascular, lymphatic and perineural invasion, solid predominant histology, higher cancer stage, and was significantly associated with worse PFS (HR = 2.27, 95% CI: 1.30–5.48, p = 0.008).
Conclusion:
Lung ADC and SqCC showed distinct IGF1R expression profiles that demonstrated prognostic significance. High membranous IGF1R expression was predictive of poor PFS in EGFR-mutant lung ADC, while was predictive of better PFS in SqCC. These findings may serve to improve study design for subsequent investigations into IGF1R and NSCLC, and to select patients for future anti-IGF1R therapy.
