Author of

• 14451

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  P2.03 - Poster Session/ Treatment of Locoregional Disease – NSCLC (ID 213)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Treatment of Locoregional Disease – NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14455

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    P2.03-004 - Surgical Outcomes of Locally Advanced Non-Small Cell Lung Cancer Invading Great Vessels and Heart (ID 3125)

    09:30 - 09:30  |  Author(s): B. Park
    • Abstract
    • Slides

    Background:
    The role of surgery has been debated in locally advanced lung cancer, especially in cases with great vessel or cardiac invasion. The aim of this study was to evaluate predictive factors and clarify whether surgical resection is beneficial in lung cancer with great vessels and heart involvement.
    
    Methods:
    Patients who were surgically treated and pathologically diagnosed as T4N0/1 non-small cell lung cancer (NSCLC) with great vessel or heart invasion were enrolled and evaluated for surgical outcomes. Patients with other structural invasion to trachea, carina, esophagus, and vertebrae were excluded. Patients with previous history of other malignant disease or double primary cancer were also excluded.
    
    Results:
    We included 50 patients and mean age was 63 9 years old. The structural involvement included main pulmonary artery (54%), pulmonary vein (38%), aorta (12%), superior vena cava (10%) and heart (10%). Complete resection was achieved in 45 patients (90%) and 5 patients underwent tumor resection under cardio-pulmonary bypass. In-hospital mortality was 12% and 5-year overall and disease-free survival rate was 44% and 40%, respectively. Multivariate analysis demonstrated that right sided cancer (p = 0.023), grossly incomplete resection (R2; p = 0.032), pneumonectomy (p = 0.029), and large cell neuroendocrine cancer (p < 0.001) were significant unfavorable prognostic factors for overall survival. NSCLC with heart invasion showed worse 5-year overall survival than NSCLC with great vessel involvement (53% vs. 20%), but did not show statistical significance (p = 0.143) due to small number of patients (Figure).Figure 1
    
    
    
    Conclusion:
    Surgical resection of locally advanced lung cancer involving great vessels or heart showed an important role with affordable outcomes.
    
    

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