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X. Wang
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MINI 32 - Topics in Localized Lung Cancer (ID 166)
- Event: WCLC 2015
- Type: Mini Oral
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:D. Boffa, T. D'Amico
- Coordinates: 9/09/2015, 18:30 - 20:00, 201+203
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MINI32.02 - Characteristics of Non-Small Cell Lung Cancer (NSCLC) Patients Who Underwent Curative-Intent Surgical Resections in China (ID 1501)
18:35 - 18:40 | Author(s): X. Wang
- Abstract
- Presentation
Background:
Lung cancer has been the leading cause of cancer related mortality for the past decades worldwide and in China. Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. For patients with early stage NSCLC, surgical resection is the mainstay of the treatment. This study aimed to better understand characteristics of NSCLC patients who underwent curative-intent lung surgical resections in China.
Methods:
Data were obtained from the NSCLC surgical outcome registry, which included 3,464 NSCLC patients who underwent curative-intent surgical resections from 13 tertiary hospitals in 11 provinces in 2013 and 2014. The registry documented detailed information on demographics as well as perioperative parameters.
Results:
The median age at the time of surgery was 60 (range 14 to 92) years, and 64.0% of the patients were male. Approximately 49.1% had a smoking history and 12.6% had a family history of cancer. About 45.7% patients had at least one comorbidity. The most prevalent comorbidities were cardiovascular disease, metabolic disease, respiratory disease, and other tumor, which affected 45.2%, 15.5%, 13.3% and 9.7% of the patients, respectively. The pulmonary function test showed a mean FEV1 of 2.33 (SD=0.63, range 0.32 to 4.81) L and FEV1/FVC of 79.3% (SD=12.6%, range 0.5% to 100.0%). The types of resection were lobectomies (lobectomies, bi-lobectomies and sleeve lobectomies) 79.3%, sublobar resections (segmentectomies and wedge resection) 8.5%, pneumonectomies 7.0%, and others 4.3%. 44.5% resections were performed by video-assisted thoracoscopic surgery (VATS). Adenocarcinoma and squamous cell carcinoma were the most common types of NSCLC, accounting for 60.2% and 31.4% of the patients, respectively. The most common tumor locations were right upper lobe (26.9%), left upper lobe (22.8%), right lower lobe (19.4%), left lower lobe (16.5%), and right middle lobe (6.5%). Pathologic staging showed 48.5% patients had stage I tumor; stage II, III, and IV accounted for 23.0%, 25.3% and 3.3%.
Conclusion:
The NSCLC patients who underwent curative-intent lung resection surgeries in China were relatively young and had good lung function. Adenocarcinoma and squamous cell carcinoma were the most common types. Nearly half of the procedures were performed by VATS and almost one out of two patients had pathologic stage I disease.
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P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.02-014 - Cross-Sectional Study on Surgical Treatment Patterns of 1927 Stage I-IIIa NSCLC Patients from 11 Medical Centers in China in 2013 (ID 3115)
09:30 - 09:30 | Author(s): X. Wang
- Abstract
Background:
Video- assisted thoracoscopic surgery (VATS) was introduced into China in 1992. Over the past two decades, VATS has experienced dramatic development in China. However, the development is imbalanced. This cross-sectional study aimed to assess the ulitility of VATS in lung cancer patients in China
Methods:
Data of non-small cell lung cancer (NSCLC) patients who received curative-intent resections during the year 2013 were obtained from the national lung cancer registry , which included 1927 patients from 11 tertiary hospitals nationwide. Surgery patterns, stations of lymph nodes dissected, operation time were analyzed.
Results:
Among the 1927 patients, the mean age was 60.0 years old, and 1228 were male. The numbers of patients in final pathologic stages 0, Ia, Ib, IIa, IIb, IIIa were 13, 571,414,243,171,495. Sublobar resection/ lobectomy/ sleeve lobectomy/ pneumonectomy number was 112/1643/57/111. The overall VATS rate is 45.0%, 71.9%, 52.2%,19.3%,6.3% in lobectomies，wedge resection, segmentectomy, sleeve lobectomy, pneumonectomy respectively . In different centers, the median number of lymph nodes stations dissected in VATS single lobectomy is 6 (ranging from 0 to 11) in different centers, while 6.5 (ranging from 0 to 11) in thoracotomy . The average VATS lobectomy surgery time is 184.0 minutes. VATS rates of lobectomy in different centers ranged from 4.4% to 90.2% respectively . VATS rates of Ia,Ib,IIa,IIb,IIIa lobectomy is 65.4%, 41.7%, 31.3%, 24.2%, 38.5% respectively.
Conclusion:
The difference of VATS rate is quite significant between different centers in China . Some centers perform 90-100% VATS in early stage patients and more VATS than thoracotomy in II and III patients. While some centers still perform over 80% thoracotomy surgeries even in stage I patients.
