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S. Uematsu
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P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.02-007 - Correlation Between Histological Invasiveness and CT Value in Pure GGNs (ID 271)
09:30 - 09:30 | Author(s): S. Uematsu
- Abstract
Background:
The purpose of this study is to evaluate the correlation between histological invasiveness and computed tomography (CT) value and size in pure ground glass nodules (GGNs) to determine optimal “follow-up or resection” strategies.
Methods:
Between 2001 and 2014, 78 resected pure GGNs were evaluated retrospectively. Maximum diameter and CT value of pure GGNs were measured using a computer graphics support system.
Results:
All GGN with a maximum diameter ≦10mm and CT value ≦-600 Hounsfield units (HU) were noninvasive lesions, while 21 of 26 (81%) with a maximum diameter >10 mm and CT value >-600 HU were invasive lesions. With respect to a correlation between each histological type and pure GGN with a maximum diameter ≦10 mm and CT value ≦-600 HU, the specificity was 90% and the sensitivity and negative predictive value were both 100% in atypical adenomatous hyperplasia (AAH), while the specificity was 58% and the sensitivity and positive predictive value were 0% in minimally invasive and invasive adenocarcinoma.
Conclusion:
In establishing follow-up criteria for pure GGNs at a maximum diameter of ≦10mm and CT value of ≦-600HU, unnecessary surgery for AAH and therapeutic delay for invasive adenocarcinoma can be avoided.
