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S. Ono
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P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.02-006 - Development of the New Photodynamic Therapy for Peripheral Type Lung Cancer (ID 2322)
09:30 - 09:30 | Author(s): S. Ono
- Abstract
Background:
In Japan, photodynamic therapy (PDT) has been recommended for the treatment of centrally located early lung cancers (CLELC). With recent advances in the diagnosis lung cancer, we continually attempt to expand the indications of PDT, not only for CLELC but also for peripheral type lung cancer. PDT for peripheral lung cancer could be one of the desirable treatment options for patients without surgical indication such as poor pulmonary function. To perform PDT for peripheral lung nodules, it is necessary to use a thin and flexible laser fiber that can sufficiently reach the peripheral lung parenchyma. In this study, we evaluated the feasibility and efficacy of a plastic laser fiber for peripheral PDT.
Methods:
A plastic fiber (cylindrical light diffuser Model RD [Medlight, Switzerland]) was used as a laser fiber for peripheral PDT. The laser output and the light irradiation distribution of the RD cylindrical light diffuser were measured and compared with those of the Panasonic cylindrical probe currently used for PDT. NPe6-PDT was performed for peripheral pig lung. One week after PDT, the pigs were dissected and the lung was removed. The efficacy of NPe6-PDT was evaluated by the pathological findings.
Results:
The mean difference in laser output and the laser source output was 17.7±1.6% for the Panasonic cylindrical fiber and 11.6±3.1% for the RD cylindrical light diffuser. For the light irradiation distribution, the RD cylindrical light diffuser was able to produce more uniform irradiation than the Panasonic cylindrical fiber. The pathological findings showed necrotic tissue and infiltration of lymphoid cells at the laser irradiation area. Around the necrotic tissue, thickening of the alveolar walls and obstruction of the vessels due to thickening of the vascular endothelium were observed.
Conclusion:
The cylindrical light diffuser Model RD showed comparable laser irradiation to the Panasonic cylindrical fiber. The animal experiment showed the effect of PDT in peripheral lung. We conclude that PDT for peripheral lung using the new fiber is feasible and could become one treatment option for peripheral lung cancer.
