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L. Liu
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P2.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 210)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.02-003 - Blood Loss Volume During Surgery Is a Significant Adverse Prognostic Factor in Patients with Stage I to IIIA Resected NSCLC (ID 2141)
09:30 - 09:30 | Author(s): L. Liu
- Abstract
Background:
There is little evidence reagrding the impact of blood loss volume during operation on long term survival. Using a large-scale multicenter database for NSCLC, we sought to investigate the prognostic value of blood loss volume.
Methods:
We collected a cohort of resected NSCLC patients from a multi-institutional registry in China (7 centers, 2001-2008) to examine the relationship between blood loss volume and overall survival (OS). According to clinical significance and expertise, blood loss volume was divided into two groups, <200 or ≥200. OS was calculated with the Kaplan-Meier method and univariate comparison between groups was performed using the log-rank test. Cox regression served as a multivariate technique.
Results:
A total of 5,762 cases were available. The mean blood loss volume was 218.4±197.2 mL, median value was 200 mL (0-5000mL). Patients who had less than 200mL blood loss during the operation had more favorable prognosis than those with blood loss of 200mL or more (median OS, 98.8 vs. 76.0 months; HR 0.756, 95% CI 0.691 to 0.829). After adjusting for sex, age, histology, T stage, N stage and operation type (complete VATS, assisted VATS and thoracotomy), blood loss volume remained an independent prognostic factor (HR 0.791, 95% CI 0.716 to 0.874). The volume of blood loss directly correlated with operation time (r=0.21, P<0.001), drainage days (r=0.17, P<0.001), days of ICU stay (r=0.11, P<0.001), drainage volume (r=0.05, P=0.04), and potentially the number of stations examined (r=0.03, P=0.06).
Conclusion:
We revealed that blood loss volume during surgery is a significant adverse prognostic factor for long-term survival. Patients with blood loss volume greater than 200mL require more attention on the recovery strategy. In addition, blood loss volume might be a comprehensive reflection of surgical trauma, and might serve as a marker for evaluating the adequacy of patient’s physical condition for receiving adjuvant chemotherapy.
