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Y. Tian
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P2.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 207)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.01-047 - Fibrobronchoscopic Cryorecanalization for Unresectable Secondary Malignant Tumors of the Trachea and Main Bronchi (ID 2367)
09:30 - 09:30 | Author(s): Y. Tian
- Abstract
Background:
Most patients with secondary malignant tracheobronchial tumors have distressing symptoms due to major airway obstruction. However, they are always too frail for curative surgical resection. We choose fibrobronchoscopic cryorecanalization to improve their life quality and analyzed the long time survival outcome.Most patients with secondary malignant tracheobronchial tumors have distressing symptoms due to major airway obstruction. However, they are always too frail for curative surgical resection. We choose fibrobronchoscopic cryorecanalization to improve their life quality and analyzed the long time survival outcome. file://localhost/Users/app/Documents/2014下半年/11122014%20JTO/冷冻/Figures/Figure%202.tif file://localhost/Users/app/Documents/2014下半年/11122014%20JTO/冷冻/Figures/Figure%201.tif file://localhost/Users/app/Documents/2014下半年/11122014%20JTO/冷冻/Figures/Figure%203.tif
Methods:
Clinical records of 14 patients were reviewed retrospectively from December 2005 to January 2013. A temperature from -50℃ to -70℃ was delivered to the central part of the tumor by cryo-probe for 4 to 6 minutes causing destruction of the tumor mass (Cryo-melt method). Subsequently, the edge of tumor was froze for 0.5 to 2 minutes and then tore the lesion piece by piece immediately with the advantage of concretion between the frozen probe tip and the tumor tissue (Cryo-resection method). file://localhost/Users/app/Documents/2014下半年/11122014%20JTO/冷冻/Figures/Figure%204.tif
Results:
The rates of dramatic and partial symptomatic alleviation were 57.1% and 28.6% respectively. There were no intraoperative deaths. The median survival was 16.0 months. Overall survival was 64.3% at half year, and 50.0% at 2 years. 2-year survival was significantly correlated to age (less than 60 years 22.2% versus more than 60 years 100%, p=0.011), tumor location (main bronchi 0% versus trachea 77.8%, p=0.003), and cryorecanalization times (one time 33.3% versus two or more times 80.0%, p=0.037). file://localhost/Users/app/Documents/2014下半年/11122014%20JTO/冷冻/Figures/Figure%205.tif file://localhost/Users/app/Documents/2014下半年/11122014%20JTO/冷冻/Figures/Figure%206.tif file://localhost/Users/app/Documents/2014下半年/11122014%20JTO/冷冻/Figures/Figure%207.tif
Conclusion:
Fibrobronchoscopic cryorecanalization is a safe, easily repeatable and effective minimally invasive choice for releasing the airway obstructive symptoms. In addition to high local-regional control rates, a rewarding result of prolonged survive time can also be obtained.
