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E. Cuestas
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P2.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 207)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.01-034 - Predictive Factors of Brain Metastases Development in Non-Small Cells Lung Cancer (ID 2291)
09:30 - 09:30 | Author(s): E. Cuestas
- Abstract
Background:
Brain metastases are evidenced in 10 to 30 % of NSCLC patients sometime during the disease. The purpose of our research is to identify the clinical pathological characteristics in patients with stage IIIB-IV in relation to the development of brain metastases.
Methods:
590 patients with lung cancer at our institution were analyzed between 2000 and 2013, of which 190 (32,3%) were stage EIIIB and 400 (67,7%) EIV. 76 (12.8%) had brain metastases. The variables included in the analysis of patients with and without brain metastases were: gender, age, histology, smoking status and ECOG. The multivariate logistic regression model was used to identify factors related to brain metastases.
Results:
64 patients out of the total 76 had brain metastases at initial diagnosis and 11 EIIIB developed brain metastasis in relapses. The development of brain metastasis was higher in men compared to women (77.7% vs 22.2%). Over 80% of patients presented ECOG of 0-1. Regarding histology, 60.32% were adenocarcinomas; 30% squamous, and 9.5% undifferentiated. 65% of patients were under 65 years old. 66.6% of patients were former smokers. Patients under 65 years old were at increased risk of developing brain metastases than older patients (HR=0,5-IC95%= 0,6-1,16- p=0,045). Adenocarcinoma histology was associated with an increased number of brain metastases development (OR = 2.42 - 95% CI = 1.84 to 3.00 - p= 0.003).
Conclusion:
Patients who were younger than 65 years old and adenocarcinoma histology, had a statistically significant higher risk of developing brain metastases. Regarding gender, we observed an increased risk in men; however, the differences were not statistically significant.
