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M. Lin



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    P2.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 207)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Advanced Diseases - NSCLC
    • Presentations: 1
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      P2.01-018 - Baseline Lymphocyte-Monocyte Ratio Is a Prognostic Marker in EGFR Mutant NSCLC Patients Receiving First Line EGFR TKIs (ID 909)

      09:30 - 09:30  |  Author(s): M. Lin

      • Abstract
      • Slides

      Background:
      Patients with higher lymphocyte to monocyte ratio (LMR) has shown to have favorable prognostic in early stage lung cancer, non-metastatic renal cell carcinoma, gastric cancer, colon cancer, pancreatic cancer and breast cancer. However, prognostic significance of LMR in patients with advanced stage, epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer receiving first line EGFR tyrosine kinase inhibitors is not well known. We conducted a retrospective analysis to investigate the influence of baseline LMR on clinical outcomes including progression free survival (PFS) and overall survival (OS) in EGFR mutant NSCLC patients.

      Methods:
      This retrospective study evaluated 253 patients harboring EGFR mutation received TKIs as first line therapy for advanced NSCLC between January 2011 and October 2013. The cut- off value determined by Receiver operating characteristic (ROC) curves for LMR was 3.29. Patients were divided into high and low LMR ratio based on above cut-off level. Kaplan–Meier analysis was used for PFS and OS estimation; and the log-rank test was utilized to examine the significance of the differences of survival distributions between groups.

      Results:
      Among 253 patients mean age was 65.2 years, 41% were male, medium PFS was 10.3 months, medium OS was 22 months. Low baseline LMR patients had shorter PFS (low vs. high: 8.2 vs 11.6m, HR: 1.508, p=0.003), and OS (low vs. high: 14.3m vs. 32.1m HR: 2.23, p<0.001) Figure 1



      Conclusion:
      Our results suggest baseline LMR is a prognostic marker for EGFR mutant NSCLC patients receiving first line EGFR-TKIs.

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