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M.Y. Baek
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P2.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 207)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.01-009 - EGFR Mutation and Brain Metastasis in Patients with Non Small Cell Lung Cancer (ID 407)
09:30 - 09:30 | Author(s): M.Y. Baek
- Abstract
Background:
It has been demonstrated that lung cancer is the most common cause of brain metastases(BM). This study was designed to analyse the association of timing and survival of BM according to histology and epidermal growth factor receptor (EGFR) mutation status in patients with metastatic nonsmall cell lung cancer (NSLCL).
Methods:
We retrospectively analysed the medical records of 268 patients with NSCLC in single center in Incheon, Korea who were tested for EGFR mutation analysis from January 2010 to August 2013. We analysed the cumulative incidence of BM regard to EGFR mutation status, the time from the diagnosis to the development of BM, the time from BM to death and median survival. Survival was estimated by the Kaplan-Meier method and compared with the log-rank test.
Results:
Out of 268 patients, 74 (28%) had BM, 54(73%) patients already at the time of diagnosis. Synchronous BM was more frequent in patient with EGFR mutation than WT EGFR patient (79% vs. 69%). But patients with metachronous BM, time to BM diagnosis was not significantly different according to EGFR status. (p=0.298) Among the 67 patients with BM, 25(37%) had mutations in EGFR, including 13 exon 19 deletions and 12 L858R mutations and 40 had WT (60%). The time from diagnosis of first brain metastases to death(BM-OS) was significantly longer in patient with EGFR mutation than WT (22.28 vs. 7.55 month, p<0.005). The BM-OS in EGFR mutated patients with synchronous BM was longer than in EGFR WT patients (25.42 vs. 8.86 month, p<0.005). But the BM-OS in EGFR mutated patients with metachronous BM was not significant different from WT EGFR patients. (p=0.16).
Conclusion:
NSCLC patients with EGFR mutations were more prevalent with synchronous BM than those with EGFR WT patients. EGFR mutation was associated with significantly longer survival from BM diagnosis, especially in those with synchronous BM.
