Author of

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  P2.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 207)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Treatment of Advanced Diseases - NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 14309

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    P2.01-003 - T-Cytotoxic Specific Immunotherapy in NSCLC with Brain Metastases NCT00104780 (ID 1202)

    09:30 - 09:30  |  Author(s): D. Costantini
    • Abstract
    • Slides

    Background:
    Brain metastases (BM) come with poor prognosis (median survival 3 to 6 months) and data are lacking as patients are often excluded from clinical trials.
    
    Methods:
    We present the results of a subgroup of NSCLC patients with BM treated with OSE-2101 (T-cytotoxic specific immunotherapy combining 9 epitopes targeting 5 tumor associated antigens and 1 pan-DR epitope) during a phase IIb study of OSE-2101 (1 injection per 3 week for 6 injections followed by 1 injection every 2 to 3 months) in advanced stage IIIB and IV NSCLC (Barve et al. 2008. J Clin Oncol 26:4418-4425). Patients were eligible whatever the number of prior chemotherapy (chemo) lines (65.5% entering 3rd line) and patients with stable BM for 2 months could be included. Six out of 64 treated patients had BM prior to inclusion and are reviewed.
    
    Results:
    

    Table 1: NSCLC patients included with BM

    Patient	108	150	169	132	133	135
    Gender	F	M	M	M	M	M
    Ethnic origin	CAU	CAU	CAU	CAU	AA	CAU
    Age (years)	46	61	58	79	46	57
    ECOG performance status	1	1	1	1	1	1
    Previous treatment	RT 30 Gy Chemo 2 lines	WBRT 30 Gy Chemo 2 lines	RT 30 Gy Chemo 2 lines	WBRT 30 Gy Chemo 3 lines	RT 30 Gy Chemo 1 line	WBRT 30 Gy Chemo 3 lines

    AA: African-American, CAU: Caucasian, Chemo: chemotherapy, F: female, Gy: Gray, M: male, RT: radiotherapy, WBRT: whole brain radiotherapy Table 2: Response to therapy

    Patient	108	150	169	132	133	135
    OS	30.16 mo	41 mo*	16.5 mo	9.6 mo	11 mo	7 mo**
    Time without progression	11.57 mo	24.39 mo	11.9 mo	4.53 mo	6.2 mo	2 mo*[2]
    CTL response (positive epitopes out of 5 tested)	3	2	5	2	1	Not tested
    HTL response	+	+	+	-	-	Not tested

    * Patient still alive at the time of the last follow up, ** treatment stopped after 2 injections for progressive disease. CTL: cytotoxic T lymphocytes, HTL: helper T lymphocytes, mo: months, OS: Overall survival, The 6 BM patients present long survival (median 13 mo, range 7-41) considering the advanced stage and the poor prognosis of these heavily pretreated patients. All patients had received from 1 to 3 previous chemo lines. Evaluation of CTL responses to 5 epitopes of OSE-2101 in 5 patients shows that each patient had a CTL response to at least one and up to 5 epitopes. Surprisingly patients with positive HTL response (patient 108, 150, 169) achieve the longest OS when compared with negative HTL patients (132 and 133).
    
    Conclusion:
    Long OS has been documented in NSCLC patients with BM treated with T-specific immunotherapy following RT and 1 to 3 previous chemo lines.
    
    

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