Author of

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  P1.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 224)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 13787

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    P1.08-033 - pRb and p16INK4 in Human Thymic Epithelial Tumors in Relation to Human Polyomavirus 7 (ID 249)

    09:30 - 09:30  |  Author(s): A. Zur Hausen
    • Abstract
    • Slides

    Background:
    We have recently reported the presence of the Human polyomavirus 7 (HPyV7) in human thymic epithelial tumors as assessed by diverse molecular techniques. Here we report on the co-expression of p16, retinoblastoma protein (pRb) and phosphoralized retinoblastoma protein (phospho-Rb) in human thymic epithelial tumors in relation to HPyV7.
    
    Methods:
    PRB, phospho-RB and p16 expression was assessed by immunohistochemistry in 37 thymomas and 2 thymic carcinomas. 17 thymomas (46%) and 1 thymic carcinoma (50%) were recently tested positive for HPyV7. In addition, 20 follicular hyperplasias were tested.
    
    Results:
    Expression of pRb was observed in 35 thymomas (94.6%), in 16 thymomas (43.2%) the expression was strong. Phospho-Rb was observed in 31 thymomas (83.8%). 19 thymomas (51.4%) showed immunoreactivity for p16 of which 8 thymomas revealed very strong p16 expression. No p16 expression was detected in thymic carcinomas. In addition, no significant correlation between the presence of HPyV7 and pRb-, phospho-Rb- and p16-expression could be established. No correlation between pRb, phospho-Rb, p16 and WHO staging, Masaoka-Koga staging or the presence of MG was found. All 20 follicular hyperplasias showed expression of pRb and less expression of phospho-Rb.
    
    Conclusion:
    Although polyomaviruses have been shown to interact with cell cycle proteins no correlation between the presence of HPyV7 and the expression of pRb, phospho-Rb and p16 in human thymic epithelial tumors was observed. In as much HPyV7 contributes to human thymomagenesis remains to be established. Our data indicate pRb, phospho-Rb and p16 expression are rather unlikely to be involved in HPyV7 related thymomagenesis.
    
    

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