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Q. Luo
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P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.04-081 - Expression of PPAR-γ Ligand in Lung Cancer and Its Effect on the Apoptosis of Lung Cancer (ID 1472)
09:30 - 09:30 | Author(s): Q. Luo
- Abstract
Background:
To explore the expression of PPAR-γ ligand in lung cancer and its effect on the apoptosis of lung cancer.
Methods:
The expression of PPAR-γ in 80 patients with lung cancer was detected using cell-culture method and its expression in the lung cancer cell lines was also determined by RT-PCR and Western blot. Additionally, TUNEL method was used to detect the apoptosis.
Results:
PPAR-γ was expressed in the lung cancer tissue and the tissue of lung benign lesions. Its optical density was the highest in the lung cancer tissue (0.1832±0.0407), then the tissue of lung benign lesions (0.1201±0.0308), and the lowest in the normal tissue (0.1185±0.0296). The total expression of PPAR-γ showed significant difference in the patients with different pathological types and differentiated degrees (P<0.05), and there was also statistical significance regarding the total expression of PPAR-γ in small cell lung cancer and non-small cell lung cancer (P<0.01). The expression of squamous cell carcinoma is the highest in non-small cell lung cancer. Significant difference was presented by comparison to the expression of PPAR-γ in poorly-differentiated and moderately, highly-differentiated lung cancer tissues (P<0.05).
Conclusion:
The expression of PPAR-γ is closely related to the pathological features of patients with lung cancer, and hence, to research PPAR-γ ligand can provide new evidences for the treatment of lung cancer.
