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H. Yoo
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P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.04-068 - Protein Tyrosine Kinase 7 Plays a Tumor Suppressor Role by Inhibiting ERK and Akt Phosphorylation in Lung Cancer (ID 3128)
09:30 - 09:30 | Author(s): H. Yoo
- Abstract
Background:
Protein tyrosine kinase 7 (PTK7) is a catalytically inactive receptor tyrosine kinase that is also known as colon carcinoma kinase-4 (CCK-4). Recent reports have shown that PTK7 plays an important role in carcinogenesis, and it is known to be up-regulated in gastric cancer, colon cancer, esophageal cancer, and liposarcoma. However, we found that PTK7 expression was down-regulated at the mRNA as well as protein levels in human lung squamous cell carcinoma (SCC), unlike in other tumors. In this study, we attempted to explore the role of PTK7 in lung cancer
Methods:
We analyzed expression of PTK7 by RT-PCR and western blot analysis using tumor and normal lung tissue from 10 SCC patients. To explore the functional role of PTK7, the expression of PTK7 in SCC cells was examined using empty vector and PTK7 gene inserted vector.
Results:
We found that PTK7 expression was down-regulated at the mRNA as well as protein levels in human lung squamous cell carcinoma (SCC). Upon investigating the functional role of PTK7 in SCC, we found that overexpression of PTK7 in SCC cells resulted in inhibition of cell proliferation, invasion, and migration. Further, we confirmed that these phenotypic changes are associated with the activation of Akt and ERK.
Conclusion:
These observations may indicate a role for PTK7 in cell proliferation, wound healing and invasion via regulating Akt and Erk activation. Our findings suggest that PTK7 has different oncogenic roles in organs and target tumors.
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-010 - Tumor Recurrence of the Chest Wall after Percutaneous Hook Wire Localization (ID 1300)
09:30 - 09:30 | Author(s): H. Yoo
- Abstract
Background:
Increasingly, localization of small lung nodule (solid or ground glass) is needed for thoracoscopic resection of accurate diagnostic and/or curative intent. Hook wire implantation is one of important localization techniques. Meanwhile, tumor recurrence in the chest wall of the percutaneous FNA tract is well known in thoracic malignancy, particularly lung cancer.
Methods:
We report the case of a 64-year-old-man with tumor recurrence of the chest wall. Eight months earlier, he underwent hook wire-guided thoracoscopic resection of RUL nodule and further anterior segmentectomy because of intraoperative diagnosis of NSCLC (squamous cell carcinoma, pT1aN0M0 IA).
Results:
Location of the chest wall tumor was coincident with the hook wire tract. The tumor was resected en-bloc, and reported as a metastatic squamous cell carcinoma. Figure 1Figure 2
Conclusion:
To reduce the risk of the tumor recurrence related with localization techniques, thoracic surgeons had better know very well the topographical anatomy of lung and avoid an unnecessary localization technique, and the wire is recommended to be withdrawn through the VATS port rather than percutaneously. This is the first report of tumor recurrence related with hook wire localization in the PubMed search.
