Author of

• 13580

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  P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Biology, Pathology, and Molecular Testing
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 13604

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    P1.04-024 - When Bone Starts Growing in the Lung: A Case Series of Pulmonary Ossifications (ID 2695)

    09:30 - 09:30  |  Author(s): J. Hendriks
    • Abstract
    • Slides

    Background:
    Pulmonary ossifications are heterotopic bone formations in the lung, previously thought to be a post-mortem finding only. Two types are described: nodular ossifications, smoothly edged, which are found in the alveoli themselves, and dendriform ossifications, branching through the alveolar septa. In this study the incidence of pulmonary ossifications was studied in a consecutive series of patients undergoing pulmonary surgery.
    
    Methods:
    From January 2008 to February 2015 19 patients with pulmonary ossifications were identified in patients undergoing thoracic surgery at Antwerp University Hospital. Diagnosis was made by the pathologist team. Neither PET nor CT was able to differentiate these ossifications from solid tumors.
    
    Results:
    15 patients (79%) were male. 8 received lung surgery for tumoral pathology. Most ossifications (58%) were found in the lower lung lobes without predilection for either chest side. 3 patients (16%) died during follow-up due to oncologic pathology unrelated to the ossifications. Most ossifications were nodular-type (12 or 63%), 6 or 32% were dendriform and one case contained both types.Figure 1
    
    
    
    Conclusion:
    Pulmonary ossifications are not as seldom as previously thought. These benign lesions are not simply a post-mortem finding and could be mistaken for a malignant space-occupying process. There appears to be a predilection for the lower lung lobes in male patients, without a clear association with other pathologies. Therefore, pulmonary ossifications deserve a place in the differential diagnosis of solitary pulmonary nodules.
    
    

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